大骨节病病区粮水对恒河猴软骨基质成分的损害作用  

Injurious effect of grain/and water from endemic areas of Kashin-Beck disease on cartilage matrix of rhesus monkey

作　　者：周秋丽[1] 常淑芳[1] 白秀起 杨春伟[1] 杨同书[1] 王金木 丁天赞 杨水珍 孙阳 付书霞 张铁锁 

机构地区：[1]白求恩医大地方病研究所 [2]洛阳地方病防治研究所

出　　处：《中国地方病学杂志》1992年第6期325-327,共3页Chinese Jouranl of Endemiology

摘　　要：蛋白多糖和胶原是软骨胞外基质的主要成分。用大骨节病病区粮水喂养18个月的恒河猴,上肢关节软骨氨基多糖的已糖醛酸、已糖胺和酯硫组分含量降低,胶原含量升高,其中以病水组动物软骨的上述改变最明显。硒对软骨基质的损伤有一定的保护作用。推测软骨胶原含量升高可能是对软骨氨基多糖减少的一种补偿。proteoglycan and collagen are main components of cartilage matrix.Rhesus Monkeys were fed for18 months on grain and water taken from endemic areas of KBD.The results showed that the contenstof uronic acid,amino hexose and sulphate decreased,and content of collagen increased in cartilage artic-ularis.These changes were most significant in the group fed on water from endemic areas.Se showedprotecting action towards the damages in cartilage matris.From the results mentioned above,we can in-fer that the enhance of collagn content is a compensative responce to the decrease of glycosaminoglycansin cartilage.

关 键 词：蛋白多糖 胶原 大骨节病 

分 类 号：R684.1[医药卫生—骨科学]