骨痛灵软膏镇痛作用的药理研究  

Pharmacological research on analgesic effect of Gutongling ointment

作　　者：李兴志[1] 李贺[1] 睢大员[2] 于晓风[2] 曲绍春[2] 

机构地区：[1]吉林大学第一医院康复疼痛诊疗中心,吉林长春130021 [2]吉林大学药学院药理学教研室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2004年第2期201-203,共3页Journal of Jilin University：Medicine Edition

基　　金：国家九五科技攻关课题 (96 - 90 1 - 0 5 - 1 5 5 )

摘　　要：目的 :观察骨痛灵软膏 (GTL O)的镇痛作用及对血液黏度的影响。方法 :通过小鼠扭体法致痛、热板法致痛、大鼠辐射热照射法致痛试验及急性血瘀模型大鼠血液黏度试验 ,对 GTL O的镇痛和改善血液黏度作用进行药理研究。结果 :GTL O对小鼠扭体法及热板法致痛 ,大鼠辐射热照射法致痛均具有明显抑制作用 ,并能明显降低急性血瘀模型大鼠的血浆黏度。结论 :GTL O对多种疼痛模型均具有明显的抑制作用 。ObjectiveTo investigate the analgesic effect of Gutongling ointment (GTLO) and its effect on viscidity of blood. MethodsAnalgesic effect of GTLO and its effect on viscidity of blood were carried through ache models induced by wring body and hot board methods in mice, by irradiation method of radiant heat in rats and test of viscidity of blood in rats with acute stasis of blood. ResultsGTLO had significant inhibitory action on ache models induced by wring body and hot board methods in mice and by irradiation method of radiant heat in rats, moreover it could reduce significantly viscidity of plasma in rats with acute stasis of blood. ConclusionGTLO has significant inhibitory effect on many experimental ache models and can improve significantly viscidity of plasma in rats with acute stasis of blood.

关 键 词：骨痛灵软膏 镇痛药 治疗应用 血液黏度 疾病模型 动物 

分 类 号：R286.1[医药卫生—中药学]