高血压患者红细胞胰岛素受体与胰岛素抵抗及内皮素的关系  

Relationships between endothelin and insulin receptor of red blood cell and insulin resistance in patients with hypertension

作　　者：佟倩[1] 郑杨[1] 徐慧[1] 

机构地区：[1]吉林大学第一医院心内科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2004年第2期256-258,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技发展计划项目 (990 5 81 - 1 )

摘　　要：目的 :探讨原发高血压病患者内皮素 (endothelin,ET)与其胰岛素抵抗 (insulin resistance,IR)及胰岛素受体的关系 ,旨在探讨高血压病的发病机理。方法 :正常对照组 (2 0例 )及高血压病组 (2 0例 ) ,在做葡萄糖耐量的同时分别采用放免法测空腹血胰岛素、ET,采用受体放射分析法测定空腹血红细胞胰岛素受体的结合容量。结果 :高血压病病人的胰岛素敏感指数 (insulin sensitivity index,ISI)及红细胞胰岛素受体的数目均低于对照组 ,ET含量高于对照组。高血压病组 ET含量与其 ISI及胰岛素受体数目均呈负性相关关系 (P<0 .0 5 )。结论 :高血压病病人存在 IR,胰岛素受体数目的减少很可能是其产生 IR原因之一。高血压病患者血中 ET含量较正常人高且与 IR有关 ,而胰岛素受体数目的变化可能是其之间联系的纽带之一。ObjectiveTo find the relationships between endothelin (ET) and insulin resistance (IR) and insulin receptor (INSR) in patients with essential hypertension. MethodsForty patients including 20 cases of essential hypertension disease (EHD) and 20 health persons were divided into experimental group and control group. Blood glucose,serum insulin,ET and the number of erythrocyte INSR in all patients during fasting condition were detected by radioimmunoassay and radiometric analysis. ResultsBoth insulin sensitivity index(ISI) and the number of INSR in EHD group were much less than that of control group, on the contrary, ET level of EHD group was significantly higher than that of control group ( P <0 05). Statistical analysis demonstrated a negative correlation between ET and ISI and INSR number existed in EHD group. ConclusionIR is a common phenomenon in patient with EHD and possiblely due to decrease of INSR number. The ET levels are higher in patients with EHD than that in health people and correlate with INSR, and the change of INSR number is the possible mediator for their relationship.

关 键 词：高血压 胰岛素敏感指数 内皮缩血管肽类 红细胞 受体 胰岛素 

分 类 号：R544.1[医药卫生—心血管疾病]