正常妊娠妇女和妊娠高血压综合征患者血浆中肾上腺髓质素的测定  

Determination of plasma adrenomedullin in normal pregnant women and pregnancy-induced hypertension patients

作　　者：阮利红[1] 李静波[1] 潘宇[2] 苑爱军 何凯[4] 朱凤全[1] 

机构地区：[1]吉林大学第二医院妇产科 [2]长春市中心医院妇产科 [3]解放军65316部队医院外科 [4]黑龙江省大庆市龙南医院

出　　处：《吉林大学学报（医学版）》2004年第2期264-266,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科学技术委员会资助课题 (990 5 6 9)

摘　　要：目的 :探讨血浆肾上腺髓质素 (ADM)与生理妊娠及妊娠高血压综合征 (妊高征 )之间的关系。方法 :应用放射免疫法测定 1 0例正常非孕妇女、 36例正常妊娠妇女 (早、中、晚期各 1 2例 )和 30例妊高征患者(轻、中、重度各 1 0例 )血浆 ADM浓度 ,所得数据行统计学分析。结果 :正常妊娠各阶段 ADM水平均高于非妊娠妇女 (P<0 .0 5 ) ,妊高征组血浆 ADM高于正常晚期妊娠组 (P<0 .0 1 ) ,轻、中、重度妊高征患者血浆 ADM水平之间比较差异有显著性 (P<0 .0 5 )。妊高征患者的平均动脉压与 ADM水平呈正相关 (r=0 .82 2 ,P<0 .0 1 ) ,低体重儿发生与妊高征的严重程度有关。结论 :ADM参与维持人类正常妊娠。在妊高征发病机制中 。ObjectiveTo study the relationships between plasma adrenomedullin (ADM) and normal pregnancy and pathogenesis of pregnancy induced hypertension(PIH) . MethodsADM concentrations in the plasma from 10 normal non pregnant women,36 normal pregnant women (12 first,12 second,12 third trimester, respectively) and 30 cases of PIH (10 mild,10 moderate,10 severe, respectively) were determined by radioimmunoassay, and data were analyzed statistically. ResultsADM concentrations in the first, second and third trimester of normal pregnancy increased significantly than that of normal non pregnant women ( P <0 05) ADM concentration in the plasma of patierts with PIH was higher than that of third trimester pregnancy ( P <0 01). There were significant differences between mild, moderate, and severe PIH groups ( P <0 05). In the PIH groups, significant positive correlation was found between plasma ADM concentration and mean arterial pressure(r=0 822, P <0 05). Incidence of low birth weight infants was related to serious degree of PIH. ConclusionADM may involve in maintaining normal human pregnancy. ADM may increase compensatorily in the pathogenesis of PIH.

关 键 词：肾上腺髓质素 妊娠 妊娠并发症 心血管 

分 类 号：R714.25[医药卫生—妇产科学]