环丙沙星对大鼠心电脑电功率谱影响的研究  

Effects of ciprofloxacin on the heart and brain electrical power spectra of rats

作　　者：周义文[1] 钱元恕[2] 陆杰[3] 范维正[3] 

机构地区：[1]重庆医科大学检验医学系,重庆400016 [2]汕头大学医学院药理教研室,汕头515031 [3]重庆医科大学基础医学院生理教研室,重庆400016

出　　处：《重庆医科大学学报》2004年第2期127-130,共4页Journal of Chongqing Medical University

基　　金：四川省教委科学基金资助项目 ( 962 72 5 )

摘　　要：目的 :观察环丙沙星对大鼠心电、脑电功率谱的影响。方法 :Wistar大鼠颈静脉注射环丙沙星 (CPLX) 10 0mg/kg体重 ,记录给前和给药后 10、2 0、30、6 0、12 0min时的心电和皮层脑电。以给药前的心电、脑电作为自身对照 ,用RR5 12软件分析心电的RR间期变异 (Variance) ,心电功率谱的低频功率 (LF)、高频功率 (HF)和LF/HF。用Coherence软件分析脑电功率谱的δ、θ、α、β波动率及总功率等指标的变化。 结果 :大鼠的心率变异性指标RR间期变异 (Va)较给药前增大 ,心电LF较给药前降低 ,心电HF则较给药前升高。给药后 10min脑电功率谱δ波动率和总功率较给药前明显降低 (P <0 .0 5 ) ,之后又逐步升高。给药后θ、α、β波动率逐步升高 ,12 0min时明显高于给药前 (P <0 .0 5 )。 结论 :CPLX可使支配大鼠心脏的交感神经活动减弱 ,迷走神经活动增强 ,因此心率变异性增大。Objective:To evaluate the effects of ciprofloxacin on the heart and brain electrical power spectra of rats.Methods:Male wistar rats received ciprofloxacin 100mg/kg through their jugular vein.The heart and brain electrical power spectra of rats were recorded before administration as contrast,and at 10,20,30,60,120 minutes after administration as experiments respectively.RR 512 soft ware was used to analyze heart electrical RR variance and low frequency power and high frequency power,and Coherence software was employed to study brain electrical δ,θ,α,β power.Results:At 10 - 6 0minafter do sage ,heartelectrical RRvariance was distinct lylarger,and low frequencypower was evidentlylower,and highfrequencypower was signi ficantly higher than those determined be foreadministration .SpikewavesfrequentlyappearedintheECOGofratsat 13minto 6 0minafteradministration .At 10minafter dosage,thebrainelectricaltotalpowerandδpowerweredistinctlylowerthanthosebeforeadministration .At 12 0min ,θ,α ,βwave powerwereobviouslyhigher,andδ/θandδ/(θ +α +β)valuewereevidentlylowerthanthosebeforeadministration ,buttheywere notchangedatothertimes.Conclusion :The excitability of sympathe ticnerv eof the heartwas weakened and the irritability of pneu mogastricnerve was enhanced ,and the hear tratevariabi lity in creases,and the excitability of centralnerve was induced by cipr of loxacin .

关 键 词：环丙沙星 心电功率谱 心率变异性 脑电功率谱 

分 类 号：R965[医药卫生—药理学] R978[医药卫生—药学]