老年原发性高血压患者的认知功能变化  

Changes of cognitive function in elderly patients with essential hypertension

作　　者：刘剑立[1] 陈继红[1] 杨绍青[1] 刘雪虹[1] 胡学军[1] 王立辉[1] 赵鸿雁[1] 王幼宏[1] 张立杰 

机构地区：[1]解放军沈阳军区总医院干一科,辽宁省沈阳市110016 [2]长春市疾病控制中心计免科,吉林省长春市130006

出　　处：《中国临床康复》2004年第12期2234-2236,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察老年原发性高血压患者认知功能损害表现,探讨其发生机制,寻求进行干预的可能性。方法:106例老年原发性高血压患者(≥60岁)接受了中国韦氏智力测试量表评估,并与相同年龄和性别的健康老人1:1配对比较。结果:老年原发性高血压患者智测成绩中填图10.7±3.4和图形排列15.8±6.2两项分测验得分明显低于对照组(14.5±4.0和22.6±10.3)(t=2.176和2.059,P均<0.05)。在按原发性高血压水平分级比较中,中重度原发性高血压患者(2～3级,48例)的算术、数字广度、填图和图形排列等项分测验得分明显低于轻度原发性高血压患者(1级,58例)(t=2.039～2.249,P均<0.05)。按有无危险因素分组比较,有危险因素(60例)的老年原发性高血压患者领悟、算术、数字广度、数字符号、填图、木块图和图形排列等项分测验明显低于无危险因素组(46例)(t=2.134～2.235,P均<0.05)。按危险性量化分层后,高和极高危患者(25例)的领悟、算术、数字广度、数字符号、填图、木块图、图形排列和图形拼凑等项分测验评分均明显低于低中危患者(t=1.957～2.329,P均<0.05)。结论:老年原发性高血压患者认知功能损害不明显,但血压水平高、合并危险因素多及危险性量化分层后,高和极高危险性老年原发性高血压患者的认知功能有较明显的障碍。AIM:To investigate the cognitive impairment in elderly patients with hypertension, and to discuss its mechanism and seek feasibility of intervention. METHODS:Totally 106 elder patients with hypertension (≥60 years old) were evaluated by Wechsler Adult Intelligence Scale Revised China(WAIS RC), and were compared with healthy subjects of the same age and sex at the ratio of 1:1. RESULTS:The scores of picture completion(PC, 10.7 (3.4) and picture arrangement (PA, 15.8(6.2) in the hypertensive group were obviously lower than those in the control group(14.5±4.0 and 22.6±10.3)(t=2.176, 2.059,P< 0.05). According to the hypertensive level classification, scores of patients with moderate, severe scale hypertension(2-3 scale, 48 cases) were significantly lower than those of mild scale hypertensive patients(1 scale,58 cases) in the tests of arithmetics(A),digit span(D),PC and PA,respectively(t=2.039-2.249,P< 0.05). According to the existence of risk factors, scores of insight, A, D, digit symbol(DS),PC,block pattern(BP) and PA tests of 60 subjects with risk factors were significantly lower than those of 46 subjects without risk factors(t=2.134-2.235,P< 0.05). With hierarchical quantity analysis of risk factors, insight,A,D,DS,PC,BP,and PA tests of 25 subjects with high or very high risk factors were significantly lower than those of subjects with mild or moderate risk factors(t=1.957-2.329,P< 0.05).Cognitive impairment was not distinct in patients with mild or moderate hypertension.Cognitive impairment of hypertensive subjects with high or very high risk factors or multiple risk factors was extraordinarily significant with hierarchical q

关 键 词：老年 原发性高血压 认知功能障碍 危险因素 并发症 韦氏智力量表 

分 类 号：R544.1[医药卫生—心血管疾病] R749.2[医药卫生—内科学]