经络实质辨析——关于经络本质与生物学基础的研究  

Discrimination of Meridian Essence--Research on Meridian Essence and Its Bioequivalence

作　　者：邓亲恺[1] 

机构地区：[1]第一军医大学生物医学工程系,广东广州510515

出　　处：《中国医学物理学杂志》2004年第2期63-66,72,共5页Chinese Journal of Medical Physics

摘　　要：本文是对作者近年关于经络本质研究工作的小结。作者首先对十余年来我国经络本质研究方面的工作进行了简略的回顾和评价,突出强调了:经络本质的研究,重点应当放在对调控人体经络生理网络的信息载体(messenger)的研究上。作者应用细胞信号转导的理论和相关实验数椐指出:当针刺穴位时,细胞产生Ca2+振荡(-在胞内)和Ca2+波(-在胞间),其幅频信号中可能蕴含有相关经络通路和生理功能调节信息;Ca2+通过与其结合的蛋白(如钙调素CaM等)参与了人体从受精、代谢、肌缩运动,直至认知、记忆等几乎所有生命过程。因此,作者猜想钙离子(Ca2+)以及配合针刺实现在细胞间Ca2+波接力传递的三磷酸肌醇(IP3)可能便是人们长期探寻的调控人体经络网络的信息载体,它们联同在经线上的细胞缝隙连接蛋白(connexon)熏构成了经络的物质基础。作者最后指出了今后进一步研究的途径和实验方法。The paper is a summary of auther recent year's research on meridian essence. At the beginning the paper gives a briefly review about decennary study of meridian essence in our country, and points out that the study of meridian essence should emphasize on the messenger which is the information carrier of regulation for the meridian physiological net. Reference the theory of cell signal transduction and the experimental data, the auther has devote a claim: when acupuncture an acupoint, it gives rise to Ca2+ oscillations (intracellular) and Ca2+ wave(intercellular), the signals' amplitude and frequency may imply informations of meridian trace routes and physiological function regulations. It's well known that Ca2+ and Ca2+ binding proteins(CaM etc.) take part in almost all process of physiology from fertilization, metabolism, muscular construction movement to cognition and memory. At last, the auther constructs a hypothesis that Ca2+ and IP3(which is required for the propagation of intercellular Ca2+ waves) are the messagers of the meridian physiological net, and they in conjuction with the gap-junction protein (connexon) build the substance bases of meridian. The auther also suggests the way of futher study.

关 键 词：经络本质 细胞分子生物学 细胞信号转导 Ca^2+振荡 Ca^2+波 三磷酸肌醇(IP3) 缝隙连接 

分 类 号：Q291[生物学—细胞生物学]