非毒性甲状腺肿人群血清甲状腺球蛋白和促甲状腺素水平相关性研究  

Correlation between serum thyroglobulin and thyroid stimulating hormone in populations with non-toxic goiter

作　　者：胡凤楠[1] 金迎[1] 滕卫平[1] 杨帆[1] 滕晓春[1] 高天舒[1] 王微波[1] 史晓光[1] 陶春梅[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110001

出　　处：《中华医学杂志》2003年第11期936-939,共4页National Medical Journal of China

基　　金：国家自然科学基金资助项目( 39970 350 );美国中华医学基金会资助项目 ( 986 88IITD)

摘　　要：目的　探讨非毒性甲状腺肿人群血清甲状腺球蛋白 (Tg)和促甲状腺素 (TSH)的相关性。方法　对缺碘和适碘地区 2 32 0名成年人进行甲状腺B超检查和甲状腺功能、甲状腺自身抗体(TAA)、尿碘测定。结果　两地区弥漫性和结节性甲状腺肿人群血清TSH水平低于同地区正常人群(P <0 0 1 ) ;缺碘地区正常人群血清TSH明显低于适碘地区正常人群 (P <0 0 0 1 )。血清Tg水平弥漫性甲状腺肿人群轻度 (P <0 0 5) ,结节性甲状腺肿人群显著高于正常人群 (P <0 0 1 ) ,后者随甲状腺体积增大而明显增加 ,前者无此现象。结论　轻度缺碘地区甲状腺肿的发生与TSH的刺激作用无直接关系。非毒性甲状腺肿存在甲状腺自主性功能。甲状腺体积增大和自主性功能不是结节性甲状腺肿血清Tg增加的主要原因 ,而大胶质滤泡退化和滤泡构造崩溃 ,使Tg漏入血循环 。Objective To investigate the correlation between serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) in populations with non toxic goiter. Methods Thyroid ultrasonography was conducted, and determination of serum triiodothyronine (FT3), thyroxin (FT4), Tg, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and TSH, and urine iodine were carried out among 609 persons with an average age of 35.4 in Panshan county, a mild iodine deficient area in Liaoning province, and 1136 persons aged 39.1 on average in Zhangwu county, an iodine sufficient area in Liaoning province, totally 2 320 persons. Results The serum TSH levels of the populations with diffuse and nodular goiter in Panshan county were (0 11±0 08) mU/L and (0 90±0 10) mU/L, significantly higher than those of the normal population in the same areas (1 33 ±0 04) mU/L, both P <0 01 The serum TSH levels of the populations with diffuse and nodular goiter in Zhangwu county were (1 29±0 13) mU/L and (0 89±0 14) mU/L, significantly higher than those of the normal population in the same areas (1 74±0 04) mU/L, both P <0 01. The serum TSH level of normal population in iodine deficient area was significantly lower than that of normal population in iodine sufficient area ( P <0 01). The serum TSH level of the normal population in Panshan County was significantly lower than that of the normal population in Zhangwu County ( P <0 01). The serum Tg level of the populations with diffuse and nodular goiter in Panshan county were (12 0±1 21) ng/L and (50 1±12 20) ng/L, significantly higher than that of the normal population in the same area (9 1±2 44) ng/L, P <0 05 and P <0 01. The serum Tg level of the populations with diffuse and nodular goiter in Zhangwu county were (12 4±2 11) ng/L and (61 2±11 86) ng/L, significantly higher than that of the normal population in the same area (7 7±2 3) ng/L, P <0 05 and P <0 01. The Tg level of the normal population in Panshan County was

关 键 词：非毒性甲状腺肿 血清 甲状腺球蛋白 促甲状腺素 相关性 发病机制 

分 类 号：R581[医药卫生—内分泌]