铜离子电化学疗法治疗痔出血及痔脱出的实验研究及临床观察  

Copper ion electrochemistry in treatment of bleeding and prolapse due to hemorrhoid, experimental and clinical studies

作　　者：李东冰[1] 王景侠[2] 常宝志[3] 黄莚庭[3] 谢向东 黄尧洲[1] 王长顺[5] 陈希琳[5] 李权[1] 王立勇 

机构地区：[1]中国中医研究院西苑医院肛肠科,北京100091 [2]北京军区总医院分院 [3]北京大学第一医院 [4]北京计然科技公司 [5]北京市二龙路医院 [6]航天工业中心医院肛肠科

出　　处：《中华医学杂志》2003年第11期958-961,共4页National Medical Journal of China

摘　　要：目的　观察利用铜离子电化学疗法治疗痔出血及痔脱出的疗效。方法　首先进行动物实验 :观察家兔止血时间及家兔肝、肾、肺间质组织血栓及血管壁水肿情况 ;观察铜质与钢质电极组织学变化并测定犬实验区与对照区铜离子浓度。再进行临床观察 :(1 )对 2 0 2例痔出血患者 (观察组 )用铜离子电化学疗法治疗 ,将铜针刺入痔区 1 0～ 1 5mm ,治疗 4min 40s,以同一方法逐一治疗各痔区。对 1 71例对照组使用痔疮宁栓及九华膏治疗。 (2 )痔脱出患者 1 2 8例为观察组 (混合痔 87例 ,内痔二期 2 9例 ,三期 1 2例 ) ,1 1 5例为对照组 (混合痔 75例 ,内痔二期 31例 ,三期 9例 )。均用铜离子电化学疗法治疗 ,观察组平均治疗脱出的痔区 9 8处 ,对照组平均治疗 3 4处。结果　 (1 )动物实验 :止血时间实验组为 (1 1 6± 0 1 8) ,对照组 (2 1 3± 0 46)min ,P <0 0 1。实验组可见大量血栓及血管壁水肿(但无上皮大量坏死 )。铜质电极作用好于钢质电极P <0 0 1。铜离子浓度 ,实验中心区 x50 7 33μg/ g ,较对照区 x1 1 63μg/ g明显增高 ,作用范围达 4cm。 (2 )临床观察 :痔出血观察组治愈率 98% ;显效率 1 5 % ;有效率 0 5 % ;无效率 0 %。对照组治愈率 1 1 1 % ;显效率 2 4 6 % ;有效率 2 8 1 % ;无效率 36 3 %?Objective To observe the effect of copper ion electrochemistry(CIE) in treatment of bleeding and prolapse due to hemorrhoid. Methods Bleeding was caused at several points on the sacrospinal muscles of 26 rabbits. Routine hemostasis was used at one side (control side) and CIE was used on the opposite side (experimental side). The stanch times at the different sides were recorded. Then the rabbits were killed. Pathological examination was made to the lung, liver, and kidney to observe the amount of small thrombus and inflammation. CIE was performed at the right side of anus of 6 dogs and the right side was used as control side. Tissue specimens of rabbit muscle and dog anus mucosa were collected to examine the copper ion concentration. A copper needle was inserted into each pile to the depth of 10～15 mm for 4′40″ (with the mean number of treated points of 9.8) upon 202 patients suffering from bleeding due to hemorrhoid, 79 with inner hemorrhoids and 123 patients with mixed hemorrhoids (experimental group). Another 171 patients suffering from bleeding due to hemorrhoid, 64 with inner hemorrhoids and 107 with mixed hemorrhoids were treated with suppository as controls. CEI was performed on 128 patients suffering from prolapse of hemorrhoid, 41 with inner hemorrhoids and 87 with mixed hemorrhoids (experimental group). Another 115 patients suffering from prolapse of hemorrhoid, 40 with inner hemorrhoids and 75 with mixed hemorrhoids were treated with suppository as controls. Biopsy specimens of anus mucosa were taken from 18 patients with mixed hemorrhoid who underwent CIE. The copper ion concentration was measured in 30 patients undergoing CIE. Results The stanch time in the experimental side of rabbit was (1.16±0.18) min, significantly shorter than that in the control side [(2.13±0.46) min, P =0.0037]. Extensive small thrombi and edema of vascular wall were seen in the rabbit liver, lung, kidney, and muscle tissues in comparison with the tissues of the control side ( P <0.01). Copper ion complex wa

关 键 词：铜离子电化学疗法 痔出血 痔脱出 临床观察 动物实验 血栓形成 血管壁炎症 

分 类 号：R657.1[医药卫生—外科学]