停用头孢噻吩、青霉素G对金黄色葡萄球菌耐药性的影响  

Study on impact of antimicrobial resistance of S.aureus in case of stopping using of Cefalotin and Penicillin G

作　　者：陈庆增[1] 张云[1] 董国英[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《山东医药》2004年第7期16-17,共2页Shandong Medical Journal

摘　　要：目的　探讨停用抗生素对细菌耐药性的影响。方法　在经验性用药中停用高耐药的头孢噻吩、青霉素 G1年 ,观察金黄色葡萄球菌对头孢噻吩、青霉素 G及其他抗生素耐药性的变化。结果　停用头孢噻吩、青霉素G1年后 ,金黄色葡萄球菌对两药的耐药率分别由 98%降至 89% (P <0 .0 5 )、96 %降至 77% (P <0 .0 1)。其他抗生素的耐药率未发生显著变化。结论　在经验性用药中停用高耐药的抗生素 ,对降低细菌耐药性有着积极的促进作用 ;细菌耐药性产生后 ,其消失是很缓慢的。Objective To study the impact of antimicrobial resistance after stoping using of antibiotics.Methods The using of Cefalotin and Penicillin G were stoped for 1 year,then the change of antimicrobial resistance of S.aureus to Cefalotin and Penicillin were observed respectively.Results The bacterial resistance rate of S.aureus to Cefalotin was reduced from 98% to 87%,P<0.05,to Penicillin G from 96% to 77%,P<0.01.Conclusions In empirical therapy stopping using antibiotics which are highly enduered by bacteria contribute to a significant decrease of bacterial resistance;Bacterial resistance is not easily reversed as long as it is formed.

关 键 词：头孢噻吩 青霉素G 金黄色葡萄球菌 耐药性 

分 类 号：R978.11[医药卫生—药品]