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作 者:孟信龙[1]
机构地区:[1]江都市人民医院内分泌科,江苏江都225200
出 处:《中国热带医学》2004年第1期41-42,共2页China Tropical Medicine
摘 要:目的 观察阿卡波糖对糖耐量异常 (IGT)人群治疗的作用。 方法 按 1999年WHO诊断标准判断的糖耐量异常 12 6例 ,随机分为饮食加运动组、阿卡波糖组 ,每组各 63例 ,并随访 1年。饮食加运动组根据个体情况制定饮食及运动方案 ;阿卡波糖组在饮食加运动控制的基础上给予口服阿卡波糖。每 3个月检测 1次空腹血糖 (FPG)及葡萄糖耐量试验 (OGTT)后 2h血糖 ( 2HPG) ,总胆固醇 (TC)、甘油三酯 (TG) ,空腹胰岛素 (FINS)和OGTT后 2h胰岛素 (PINS)水平的变化。 结果 1年后 ,饮食加运动组FPG轻度上升 ,2HPG下降 ,糖尿病的发病率为 9 5 % ;阿卡波糖组FPG及2HPG均明显下降 ,糖尿病的发病率为 3 2 % ,两组差异有显著性 (P <0 0 5 )。而两组人群胰岛素分泌治疗前后差异无显著性 (P >0 0 5 )。 结论 阿卡波糖能够降低IGT人群糖尿病的发病率 ,且不增加胰岛素的分泌。Objective To observe the results of intervening treatment of abnormal inhibition glucose tolerance (IGT) subjects with acarbose. Methods One hundred and twenty-six IGT subjects were,according to the WHO diagnostic criterion,randomly divided into two groups,the Diet+Exercise Group (Group Ⅰ) and Acarbose Treatment Group (Group Ⅱ),each consisted of 63 subjects and followed up for one year.The subjects in Group Ⅰ were only treatment with diet plus exercise,while those in Group Ⅱ were treated with diet plus exercise and orally given acarbose.of 50mg,three times per day.The variations of fasting plasma glucose (FPG),postprandial plasma glucose (2HPG),total cholesterol(TC),total triglyceride (TG) 2 hours after oral glucose tolerance test (OGTT),insulin(PINS) two hours after fasting insulin and OGTT were determined once per three months. Results There were no differences between the two groups before the experiment and a year after the experiment FPG in Group Ⅰ increased slightly and HPG decreased and with an incidence of diabetes of 9.5%.The FPG abd HGP in Group Ⅱ markedly decreased and with an incidence of diabetes of 3.2%,showing a significant diference as compared with that of Group Ⅰ (P<0.05).There were no differences in secretion of insulin between the two groups before and after treatment. Conclusion Application of acarbose in the intervening treatment of IGT subjects can reduce the incidence of diabetes and without increase the secretion of insulin.
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