二异氰酸酯扩链合成聚乳酸类药物缓释材料的研究——Ⅱ.溶液法  

Studies on the Synthesis of Polylactic Acids Drug Delivery Material through Diisocyanate Chain Extension.Ⅱ.Solution Method

作　　者：汪朝阳[1] 王浚[1] 赵耀明[1] 王方[1] 游革新[1] 

机构地区：[1]华南理工大学材料学院

出　　处：《合成材料老化与应用》2004年第1期1-4,40,共5页Synthetic Materials Aging and Application

基　　金：高等学校博士学科点专项科研基金(98056110);广东省自然科学基金(020885)

摘　　要：以D,L-乳酸直接合成的低分子量聚外消旋乳酸(PDLIA)为原料,通过二异氰酸酯扩链合成聚乳酸类药物缓释材料,采用2,4-甲苯二异氰酸酯(TDI)为扩链剂,反应在四氢呋喃溶液中进行,扩链反应工艺条件为:在SnCl_2催化下,NCO/OH摩尔比=1～2:1时,66℃下回流反应1～1.5h,分子量可增加3倍以上。与熔融扩链法相比,进一步提高了以乳酸为初始原料合成聚乳酸类药物缓释材料的利用率,且反应条件更为温和、易于调控。Starting from lower molecular weight poly(D, L-lactic acid) (PDLLA) via direct polycondensation of D, L-lactic acid, polylactic acids drug delivery material was sgnthesized through diisocyanate chain extension. Using 2, 4- toluylene diisocyanate (TDI) as chain extender and tetrahydrofuran (THF) as solvent, the conditions for the chain extension synthesis were studied. Catalyzed by SnCl_2, under the reaction conditions including NCO/OH mol ratio 1.0 ～ 2.0, reflux temperature 65 ～ 66℃ and time 1 ～ 1.5h, viscosity-average molecular weight (M η) of chain extension product could be more than 3 times higher than before. Compared with the TDI chain extension in melt state, the solution method had more mild condition, which was more apt to control. The novel chain extension method also further increased the yield of polylactic acids drug delivery material starting from D, L-lactic acid.

关 键 词：2 4-甲苯二异氰酸酯 聚乳酸 药物 缓释材料 扩链剂 四氢呋喃 扩链反应 回流反应 分子量 

分 类 号：TQ463.2[化学工程—制药化工] TQ225.24