动态血压监测评价复方厄贝沙坦的降压作用  

Evaluation of the antihypertensive effect of Irbesartan/Hydrochlorothiazide combination assessed by ambulatory blood pres- sure monitoring

作　　者：唐斌[1] 诸骏仁[1] 蔡乃绳[1] 柏瑾[1] 西雁[1] 

机构地区：[1]复旦大学附属中山医院心内科,200032

出　　处：《国外医学（心血管疾病分册）》2004年第2期114-115,共2页

摘　　要：目的:评价厄贝沙坦/氢氯噻嗪(复方厄贝沙坦,商品名安博诺)降压谷/峰比值及降压效果。方法:开放试验。28例轻中度高血压患者日服一次复方厄贝沙坦(厄贝沙坦150mg/氢氯噻嗪12.5mg)、共8周,治疗前后行24h动态血压监测。结果:收缩压、舒张压谷/峰比值分别为56.1％、55.3％,24h、昼、夜平均血压分别下降22.2/13.3mmHg、23.8/14.1mmHg、15.0/9.1mmHg。结论:复方厄贝沙坦日服一次,降压作用可维持24h。Objective: To evaluate the trough/peak(T/P) ratio and antihypertensive effects of Irbesartan/Hydrochlo-rothiazide combination. Methods: Opened clinical trial. 28 patients with mild to moderate hypertension took Irbesartan/ Hydrochlorothiazide combination once a day for 8 weeks. 24h Ambulatory blood pressure monitoring was done before and after treatment respectively. T/P ratios were calculated. Results: The mean trough/peak ratios of SBP and DBP in re-sponders were 56. 1% and 55. 3% ,mean 24h blood pressure decreased 22. 2/13. 3mmHg,mean blood pressure of daytime and nighttime decreased 23. 8/14. 1mmHg and 15. 0/9. 1mmHg. Conclusions: Therapy with Irbesartan/Hydrochlorothiazide combination once a day can provide reduction of blood pressure for 24 hours.

关 键 词：动态血压监测 复方厄贝沙坦 降压药 高血压 靶器官损害 

分 类 号：R96[医药卫生—药理学]