苯并(a)芘、芘及其混合物暴露对梭鱼肝脏谷胱甘肽硫转移酶活性的影响  

The effect of exposure of Benzo(a)Pyrene,Pyrene and their mixture on hepatic glutathione-s-transferases activity in Mugil so-iuy

作　　者：王重刚[1] 陈奕欣[1] 郑微云[2] 余群[2] 

机构地区：[1]厦门大学生命科学学院,福建厦门361005 [2]厦门大学环境科学研究中心,福建厦门361005

出　　处：《海洋科学》2004年第3期40-43,共4页Marine Sciences

基　　金：国家自然科学基金资助项目(49876029)

摘　　要：在实验生态条件下 ,观察苯并(a)芘、芘及其等浓度混合物暴露对梭鱼(Mugilso-iuy)肝脏谷胱甘肽硫转移酶 (GST)活性的影响。结果显示 ,在7d的暴露中 ,苯并(a)芘、芘对肝脏GST活性的影响主要为诱导效应 ,芘对GST活性的诱导比苯并(a)芘强。混合物在15d的暴露中未观察到GST活性的诱导 ,而是在暴露的后期出现GST活性的抑制。实验表明 ,肝脏GST活性的诱导指示受到PAHs污染胁迫 ,而GST活性抑制则是受到较长时间或较严重的污染。The effects of benzo(a)pyrene(BaP),pyrene and their mixture of equal concentration exposure on hepatic glutathione s-transferases(GST)activity in Mugil so-iuy were studied in experimental condition.The results showed that the GSTactivities were mostly induced in the fish exposed to BaP or pyrene during7days exposure.Pyrene seems to have a stronger ability inducing GSTactivity than BaP.No GSTactivity inducins were observed in the fish exposed to the mixture during a15day exposure,while the GST activity were inhibited at the anaphase of the exposure.These results suggested that the hepatic GSTactivity induction indicate PAHs pollution,while the GSTactivity inhibition indicate more grievous or long lasting pollution.

关 键 词：苯并(A)芘 芘 谷胱甘肽硫转移酶 梭鱼 活性 污染 肝脏 多环芳烃 GST 

分 类 号：X503.225[环境科学与工程—环境工程] X834