围生期血栓前状态分子标志物的检测  

Examine the changes of relative variables about prethrombosis state in pregnant or postpartum

作　　者：钟梅[1] 刘宝瑛[2] 余艳红[1] 崔宝奎[1] 

机构地区：[1]第一军医大学南方医院妇产科,广州510515 [2]广东省广州市胸科医院妇科,广州510095

出　　处：《广东医学》2004年第4期392-394,共3页Guangdong Medical Journal

基　　金：广东省重大社会问题攻关基金资助项目 (编号 :2KB0 470 1S)

摘　　要：目的　研究具有高危因素的孕产妇血栓前状态相关分子标志物的变化。方法　选取具有高危因素的孕产妇 2 5 8例、正常晚期妊娠妇女 2 0例及门诊体检健康非妊娠妇女 2 0例 ,分别测定各组血浆中血管性血友病因子 (vWF)、血小板α -颗粒膜蛋白 (GMP - 14 0 )、抗凝血酶 -Ⅲ (AT -Ⅲ )、蛋白C系统筛选 (PCATProCGlobal)、纤维蛋白原 (Fbg)、纤溶酶原 (PLG)、组织纤溶酶原激活物 (t-PA)及其抑制物 (PAI)、D -二聚体 (D -Dimer)的含量。结果　正常妊娠时血浆内vWF ,PLG ,PAI,D -Dimer,Fbg含量升高 (P <0 0 1) ,AT -Ⅲ降低 (P <0 0 1) ,而GMP - 14 0 ,PCAT ,t-PA则无显著性变化 (P >0 0 5 ) ;具有高危因素的孕产妇较同龄孕产妇血浆内vWF ,GMP - 14 0 ,PLG ,PAI,D-Dimer,Fbg含量明显升高 (P <0 0 1) ,PCAT ,AT -Ⅲ显著降低 (P <0 0 1) ,而t -PA则无显著性变化 (P >0 0 5 )。结论　妊娠期妇女尤其是具有高危因素的孕产妇血液处于明显的血栓前状态 ;对孕产妇 。Objective To study the changes of the hemorrheology coagulation and fibrinolytic system in patients with increased risk factors. Methods Plasma were collected from perinatal women with in creased risks, non-pregnant and normal late pregnant women in Nanfang hospital. vWF, GMP-140, t-PA, PLG, Fbg, D-Dimer, PAI and AT-Ⅲ in plasma were defermined. Results vWF, GMP-140, Fbg, PLG, D-Dimer and PAI in high risk patients were significantly higher than those of control group. AT-Ⅲ and PCAT were lower than those of control group(P<0.01). t-PA had no significant differences(P>05). Conclusion Prothrombotic state occured in normal of late pregnancy women, especially in high risk pregnancy.

关 键 词：围生期 血栓前状态 分子标志物 PTS 诊断 妊娠 

分 类 号：R55[医药卫生—血液循环系统疾病]