薏苡仁注射液对小鼠移植性S180肉瘤血管形成抑制的作用  

Experimental Study on Inhibiting Angiogenesis in Mice S180 Sarcoma by Coix Lacryma-Jobi Injection

作　　者：冯刚[1] 孔庆志[1] 黄冬生[2] 黄涛[3] 卢宏达[1] 费雁[1] 冯觉平[1] 

机构地区：[1]武汉市普爱医院肿瘤科,430033 [2]湖北中医学院 [3]华中科技大学同济医学院

出　　处：《肿瘤防治研究》2004年第4期229-230,248,共3页Cancer Research on Prevention and Treatment

基　　金：武汉市卫生局资助项目 (编号 :2 0 0 2 2 19 2 7)

摘　　要：目的　探讨薏苡仁注射液对肿瘤血管形成抑制作用。方法　通过建立动物肿瘤模型 ,运用薏苡仁实验治疗 ,检测其抑瘤率和肿瘤内血管密度 ,以及瘤体VEGF和bFGF表达的改变。结果　薏苡仁具有明显的抑制S180肉瘤生长作用。实验组的S180瘤体内微血管密度均明显低于对照组 ;免疫组化显示薏苡仁大、中剂量组均可下调S180瘤体内VEGF、bFGF的表达。结论　薏苡仁注射液对肿瘤血管形成均有明显抑制作用 ,降低VEGF、bFGF的表达可能是其抑制肿瘤血管形成的主要机制之一。Objective To investigate the effect of inhibiting angiogenesis by coix lacryma-jobi.Methods The tumor inhibitory rate and the vascular density were tested in animal tumor model with experimental treatment. The expression of VEGF and bFGF were measured by immunohistochemistry.Results Coix lacryma-jobi has inhibitory effect on S180 sarcoma and the vascular density of S180 sarcoma were lower than the control group. The expression of VEGF and bFGF were down-regulated when the middle and high dose were used.Conclusion Coix lacryma-jobi injection has inhibitory effects on S180 sarcoma and strong inhibitory effects on angiogenesis. Its mechanism may be associated with the down-regulating of VEGF and bFGF expression.

关 键 词：薏苡仁注射液 小鼠 移植性S180肉瘤 血管形成 肿瘤抑制 血管内皮生长因子 碱性成纤维细胞生长因子 中医药疗法 

分 类 号：R285.5[医药卫生—中药学] R273[医药卫生—中医学]