充血性心力衰竭患者肱动脉流量介导性舒张功能异常及生脉液的治疗作用  

Effects of Shengmai injection on congestive heart failure patients with abnormal flow-mediated dilation of brachial artery volume

作　　者：何友作 李秀华[1] 李春勇[1] 赵旭芬 李婉林 刘正辉[1] 高兴玉[2] 

机构地区：[1]南部县人民医院,四川南部637300 [2]川北医学院附属医院,四川南充637000

出　　处：《心脏杂志》2004年第2期137-139,共3页Chinese Heart Journal

摘　　要：目的 :观察充血性心力衰竭 (CHF)患者肱动脉流量介导性舒张 (FMD)功能变化及生脉液的干预作用。方法 :CHF患者 6 0例随机分两组 :常规治疗组 (2 8例 ) ,予常规抗心衰治疗。生脉液组 (32例 ) ,在常规治疗的基础上加用生脉液 2 0～ 4 0 m l静滴 ,1次 / d。疗程 14 d。疗程前后分别进行肱动脉血管超声检测及运动耐量试验。正常对照组2 0例 ,不予任何治疗。结果 :1生脉液组临床总有效率显著高于常规治疗组 (P<0 .0 1) ,心衰纠正时间较常规治疗组显著缩短 (P<0 .0 1) ,运动耐受时间较常规治疗组显著延长。 2 CHF患者肱动脉 FMD活性较正常对照组显著减弱 (P<0 .0 1)。3生脉液组生脉液干预后肱动脉 FMD活性显著增强 ,与常规治疗组比较有显著差异 (P<0 .0 1)。结论 :CHF患者存在明显的血管内皮依赖性舒张功能障碍。生脉液通过增强 FMD活性 ,对该病具有治疗作用。AIMTo observe the effect of Shengmai injection on congestive heart failure(CHF) patients with abnormal flow-mediated dilation(FMD) of brachial artery volume. METHODS:60 patients were randomly divided into two groups:the routine treatemtn group(n=28), who were given anti-failure therapy and the Shengmai injection treatment group (n=32),who were treated by combination of routine therapy and Shengmai injection which was given by intravenous infusion of 20~40 ml,once a day for 14 days. Brachial artery blood vessel ultrasonic examination and movement tolerance test were performed before and after the therapy. The routine therapy group(n=20) were not given any treatment. RESULTS:① It was found that the total clinical effective rate of the Shengmai injection group was significantly higher than that of the routine treatment group. The time for heart failure correction was greatly shortened and the time for movement loerance was also significantly prolonged in the Shengmai injection group.compared with the routine treatment group. ②the activity of FMD of brachial artery of the CHF patients was significantly weakend compared with that of the control group(P<0.01). ③The activity of FMD of brachial artery was significantly strengthened after Shengmai injection therapy,which was remarkably different from that of the routine treatment group(P<0.01). CONCLUSION:As shengmai injection therapy the obvious dependent dilate function disorders CHF patients suffer could correct by strengthening the FMD activity of brachial artery. shengmai injection is an efficacious drug for treating CHF patients.

关 键 词：心力衰竭 充血性 内皮功能 超声 多普勒 生脉液 

分 类 号：R541.61[医药卫生—心血管疾病]