胃复春治疗胃粘膜异型增生临床观察及对p21^(ras)和p53表达的调节作用  被引量：24

udy on Weifuchun Pill in the Treatment of Gastric Mucosal Dysplasia and its Regulative Effect on the Expression of P21^(ras) and P^(53) Protein</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=9417445' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('5jK90P3JxfzXwiDk/3G50YMwLgbQOqAH05pocYb9Ufk=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="5jK90P3JxfzXwiDk/3G50YMwLgbQOqAH05pocYb9Ufk="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input 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href='/zk/search.aspx?key=A%3d%5b%e5%a7%9a%e6%a1%82%e8%8a%b9%5d' title='姚桂芹[1]'>姚桂芹[1]</a> <a href='/writer/article.aspx?id=100000008884629' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%9f%a9%e8%8e%89%5d' title='韩莉[1]'>韩莉[1]</a> <a href='/writer/article.aspx?id=100000007821516' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%96%9b%e5%bc%ba%5d' title='薛强[2]'>薛强[2]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=673079&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%b3%b0%e5%b1%b1%e5%8c%bb%e5%ad%a6%e9%99%a2%e7%ac%ac%e4%ba%8c%e9%99%84%e5%b1%9e%e5%8c%bb%e9%99%a2%e6%b6%88%e5%8c%96%e7%a7%91' title='[1]泰山医学院第二附属医院消化科,济南250031'>[1]泰山医学院第二附属医院消化科,济南250031</a> <a href='/organ/article.aspx?id=673079&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%b3%b0%e5%b1%b1%e5%8c%bb%e5%ad%a6%e9%99%a2%e7%ac%ac%e4%ba%8c%e9%99%84%e5%b1%9e%e5%8c%bb%e9%99%a2%e7%97%85%e7%90%86%e7%a7%91' title='[2]泰山医学院第二附属医院病理科'>[2]泰山医学院第二附属医院病理科</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=98320A' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e4%b8%ad%e5%9b%bd%e4%b8%ad%e8%a5%bf%e5%8c%bb%e7%bb%93%e5%90%88%e6%b6%88%e5%8c%96%e6%9d%82%e5%bf%97%5d' title='中国中西医结合消化杂志'>《中国中西医结合消化杂志》</a>2004年第2期95-97,共3页<em>Chinese Journal of Integrated Traditional and Western Medicine on Digestion</em></p><p class='abstrack'><strong>摘　　要：</strong>目的:研究胃复春片对胃粘膜中、重度异型增生的治疗作用及对p21ras、p53蛋白表达的调节作用,探讨其逆转胃癌前病变的价值及机制。方法:内镜下病理活检证实为中、重度异型增生病例共58例。随机分为胃复春治疗组32例,维酶素对照组26例,治疗前后比较临床疗效,镜下改变、病理改变及粘膜p21ras、p53蛋白S-P法免疫组化染色变化情况。结果:胃复春组临床症状的总有效率81.25％,内镜下改变总有效率71.88％、病理学改变总有效率65.63％,均优于维酶素对照组(分别为53.85％、46.15％、34.61％)。p21ras、p53蛋白在中、重度异型增生组织中有过度表达,胃复春能使其表达明显减弱。结论:胃复春对胃粘膜中、重度异型增生有良好的治疗作用,能促进病变胃粘膜的逆转,并对p21ras、p53蛋白的表达有一定的调节作用,降低癌变危险性,是治疗胃癌前病变的有效药物。<em><abstract>jective:To determine the effect of Weifuchun pill (WP) on gastric mucosal dysplasia and its regulative effect on the expression of p21ras and p53 protein. Methods:Fifty-eight patients with endoscopically and pathologically confirmed moderate or severe dysplasia were classified randomly into 2 groups. Among them 32 patients were treated with WP and 26 patients with Weimeisu as control. Expression of p21ras and p53 protein was detected by S-P immunohistochemical method before and after the treatment. Results: The therapeutic effect on clinical symptoms, pathological and endoscopical changes of WP were better than that of control group. Over-expression of p21ras and p53 protein was found in both groups before the treatment and WP reduced both of them. Conclusion: WP has good therapeutic effect on gastric mucosal dysplasia and regulative effect on the expression of p21ras and p53 proteins. It could reduce the risk of carcinogenesis of gastric precancerous lesions as an effective medicine.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=3897598' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%83%83%e5%a4%8d%e6%98%a5%5d' title='胃复春'>胃复春</a> <a href='/subject/article.aspx?id=3900549' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%83%83%e7%b2%98%e8%86%9c%e5%bc%82%e5%9e%8b%e5%a2%9e%e7%94%9f%5d' title='胃粘膜异型增生'>胃粘膜异型增生</a> <a href='/zk/search.aspx?key=K%3d%5b%e4%b8%b4%e5%ba%8a%e8%a7%82%e5%af%9f%5d' title='临床观察'>临床观察</a> <a href='/zk/search.aspx?key=K%3d%5bp21%5eras%e5%9f%ba%e5%9b%a0%5d' title='p21^ras基因'>p21^ras基因</a> <a href='/zk/search.aspx?key=K%3d%5bp53%e5%9f%ba%e5%9b%a0%5d' title='p53基因'>p53基因</a> <a href='/zk/search.aspx?key=K%3d%5b%e8%9b%8b%e7%99%bd%e8%a1%a8%e8%be%be%5d' title='蛋白表达'>蛋白表达</a> <a href='/subject/article.aspx?id=4699042' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%85%8d%e7%96%ab%e7%bb%84%e5%8c%96S-P%e6%b3%95%5d' title='免疫组化S-P法'>免疫组化S-P法</a> <a href='/zk/search.aspx?key=K%3d%5b%e7%99%8c%e5%89%8d%e7%97%85%e5%8f%98%5d' title='癌前病变'>癌前病变</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR259.73' title='R259.73'>R259.73</a>[<a href = '/domain/article.aspx?id=467' >医药卫生—中西医结合</a>] <a href='/zk/search.aspx?key=C%3dR285.6' title='R285.6'>R285.6</a>[<a href = '/domain/article.aspx?id=456' >医药卫生—中医内科学</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=9417445" name="flashVars"> <embed width="695" height="250" 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