万拉法新与氟西汀治疗抑郁症对照研究  

A control study between venlafaxine and fluoxetine in the treatmeni of depression

作　　者：刘文庭[1] 杨长虹[1] 郭华[1] 尤海峰[1] 

机构地区：[1]驻马店市精神病医院,河南驻马店463000

出　　处：《临床心身疾病杂志》2004年第1期11-12,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 比较万拉法新与氟西汀治疗抑郁症的疗效与副作用。方法 将符合CCMD-3抑郁症诊断标准的60例患者随机分为万拉法新组(30例)和氟西汀组(30例),疗程6w。治疗前及治疗1、2、4、6w末分别采用HAMD、CGI-SI、TESS进行评定。结果 两组总有效率和副反应发生率无显著性差异(P>0.05),而第2w两组间HAMD评分有显著性差异(t=2.50,P<0.05)。结论 万拉法新抗抑郁作用起效较快,疗效及副反应与氟西汀相当。Objective To compare the efficacy and side effects between venlafaxine and fluoxetine in the treatment of depression. Methods 63 patients with depression (met the criterion of CCMD - 3 for depression) were randomly divided into venlafaxine and fluoxetine groups treated for six weeks and assessed by HAMD,CGI-SI and TESS before treatment and in 1st ,2nd,4th and 6th week of the treatment . Results There was no significant difference in total effective rate and side effects (P>0. 05) ,but significant difference in the scores of HAMD in 2nd week between 2 groups (y = 2. 5,P<0. 05). Conclusion Venlafaxine takes effect more quickly and its efficacy and side effects are similar to fluoxetine's.

关 键 词：万拉法新 氟西汀 抑郁症 

分 类 号：R395.6[哲学宗教—心理学]