儿童脑室周围白质软化症的MRI与临床对比研究  

Correlation between MRI and clinical profiles of periventricular leukomalacia in children

作　　者：范晓颖[1] 肖江喜[1] 蒋学祥[1] 唐光健[1] 

机构地区：[1]北京大学第一医院放射科,100034

出　　处：《中华放射学杂志》2003年第3期268-271,共4页Chinese Journal of Radiology

摘　　要：目的　分析儿童脑室周围白质软化症 (PVL)的MRI表现与妊娠时间与临床症状的关系。方法　搜集 3 4例有晚期PVL典型表现的病例 ,按早产组及足月组分析其MRI改变 ,包括脑室周围异常高信号、皮质或皮层下白质的损伤和脑白质减少程度与相应的临床症状。结果　 (1)早产组T2 WI脑室周围高信号程度较足月组重 ,Z值为 3 840 ,P值为 0 0 0 0 ;(2 ) 19例足月组PVL中 9例有皮质或皮层下白质的损伤 ,而早产儿仅占 1/ 15 ,P值为 0 0 2 0 ;(3 )足月组有抽搐表现者较早产组多见 ,P =0 0 3 6;(4)两组的运动障碍和智力落后均与脑白质减少严重程度相关 ,运动障碍Z =- 3 0 47,P =0 0 0 2 ;智力落后Z =- 3 786,P =0 0 0 0 ,智力落后与胼胝体发育不良有关 (Z =- 2 499,P =0 0 12 ) ,早产组视力异常与脑白质减少相关。结论　MRI可清楚显示PVL的病变程度及范围 。Objective To study the relationship between MRI and clinical profiles of periventricular leukomalacia (PVL) in children Methods The clinical and MRI findings in 34 cases with PVL were retrospectively analyzed Results (1) Periventricular hyperintensity on T 2WI was more prominent in the preterm group than that in the term group, and P value was 0 000; (2) Cortical lesion and subcortical leukomalacia was seen in 9 of 19 cases in the children with PVL born at term, but detected in only 1/15 in the preterm group P value was 0 020; (3)Seizure was common in term children P value was 0 036; (4) The degree of reduction of periventricular white matter correlated with motor impairment and mental retardation in all children, and P values were 0 002 and 0 000, respectively The thinning of the corpus callosum also correlated with mental retardation and P value was 0 012 The degree of reduction of periventricular white matter correlated with visual impairment in preterm group Conclusion The end stage PVL can been clearly displayed by MRI, and gestational age and clinical manifestation were closely related to the findings of MRI

关 键 词：儿童 脑室周围白质软化症 MRI 对比研究 

分 类 号：R445.2[医药卫生—影像医学与核医学]