疣毒净对复发性尖锐湿疣患者淋巴细胞凋亡调控蛋白的影响  

The influence of Youdujing on lymphocyte apoptosis-modulated protein in recurrent condyloma acuminatum

作　　者：江光明[1] 禤国维[1] 范瑞强[1] 

机构地区：[1]广东省中医院皮肤科

出　　处：《中国麻风皮肤病杂志》2003年第6期553-554,共2页China Journal of Leprosy and Skin Diseases

基　　金：广东省自然科学基金题 (编号 :0 0 356)

摘　　要：目的 :　观察中药疣毒净系列制剂对复发性尖锐湿疣患者淋巴细胞凋亡调控蛋白的影响。方法 :　选择经疣毒净系列制剂治疗前、后复发性尖锐湿疣患者血液行淋巴细胞凋亡调控蛋白Bcl - 2、CD95 + 、CD95L的检测并与健康人群进行对照。结果 :　复发性尖锐湿疣患者治疗前后CD95 + 、CD95L表达水平高于健康对照组 ,Bcl- 2则低于健康对照组 (P<0 .0 5 ) ,而治疗前组CD95 + 、CD95L表达水平分别高于治疗后组 (P <0 .0 5 ) ,Bcl- 2则低于治疗后组 (P <0 .0 1)。结论Objective: To determine the influence of lymphocyte apoptosis-modulated protein in the patients with recurrent condyloma acuminatum (CA) treated with Youdujing (YDJ). Methods: Apoptosis modulated proteins Bcl-2, CD95 + and CD95L were detected in the patients with recurrent CA before and after treatment with YDJ and compared with normal controls.Results: Before or after the treatment with YDJ, the expressions of CD95 + and CD95L was higher in patients with recurrent CA than that in normal controls while the expression of Bcl-2 was lower in the patients than that in normal controls (P<0.05). In addition, the expression of CD95 + and CD95L was higher before the treatment with YDJ than that after the treatment with YDJ (P<0.05), while the expression of Bcl-2 was higher after treatment than that before treatment (P<0.01). Conclusion : The ability of anti-apoptosis has significantly increased in the patients treated with YDJ.

关 键 词：疣毒净 复发性尖锐湿疣 淋巴细胞 细胞凋亡 凋亡调控蛋白 Bcl-2 CD95^+ CD95L 检测 

分 类 号：R752.53[医药卫生—皮肤病学与性病学] R978.7[医药卫生—临床医学]