孕期四氯二苯对二噁英处理对子鼠颌下腺表皮生长因子和表皮生长因子受体的影响  

EFFECTS OF IN UTERO EXPOSURE OF TCDD ON SYNTHESIS OF EPIDERMAL GROWTH FACTOR AND EPIDERMAL GROWTH FACTOR RECEPTOR IN SUBMANDIBULAR GLAND OF RAT OFFSPRINGS

作　　者：韩笑宁[1] 王笑海[1] 何威[1] 

机构地区：[1]中国医科大学组织学胚胎学教研室,沈阳110001

出　　处：《解剖学报》2003年第2期221-224,共4页Acta Anatomica Sinica

基　　金：辽宁省自然科学基金资助项目 ( 0 0 2 0 3 6)

摘　　要：目的　研究孕期四氯二苯对二英 (TCDD)处理对子鼠颌下腺表皮生长因子 (EGF)和表皮生长因子受体 (EGFR)的影响。　方法　孕 15d大鼠给予TCDD(5 μg kg)灌胃 1次 ,采用免疫组织化学方法 ,对不同发育阶段的子鼠颌下腺进行了观察。　结果　在PND32 ,PND4 9d ,TCDD组颌下腺EGF和EGFR的免疫反应阳性产物比对照组丰富 ,有显著性差异。　结论　孕期TCDD暴露促进了青春期和青春前期子鼠颌下腺EGF的生成和EGFR的表达。Objective To study the effect of in utero exposure of TCDD on synthesis of EGF and EGFR in submandibular gland of rat offspring. Methods SD rats were treated with TCDD 5?μg/kg on Day 15 of gestation, the expression of EGF and EGFR in submandibular gland of rat offspring were analyzed by immunohistochemistry method. Results On PND32 and PND49, the expression of EGF and EGFR in TCDD experiment group were more than that of control group, the difference was statistically significant.Conclusion In utero exposure of TCDD can promote the synthesis of EGF and EGFR in submandibular gland of rat offspring from prepuberty stage through puberty stage. [

关 键 词：孕期 四氯二苯对二噁英 处理 颌下腺 表皮生长因子 表皮生长因子受体 

分 类 号：R714.1[医药卫生—妇产科学]