大疱性类天疱疮抗原2在毛发周期不同阶段的表达情况  

BPAG2 expression in different growth stages of hair follicle

作　　者：吴艳[1] 王莹[1] 秦俭[1] 张波[2] 朱学骏[1] 

机构地区：[1]北京大学第一医院皮肤科,100034 [2]北京大学病理系,100083

出　　处：《中国麻风皮肤病杂志》2003年第3期201-204,共4页China Journal of Leprosy and Skin Diseases

基　　金：教育部博士点基金课题200115002

摘　　要：目的 :　研究大疱性类天疱疮抗原 2 (BPAG2 )在毛发周期不同阶段的表达情况及其对毛发生长和毛发周期的影响。方法 :　间接免疫荧光、免疫组化、透射电镜和原位杂交。结果 :　BPAG2和其它基底膜相关分子如层粘连蛋白一样 ,在整个毛发周期中持续表达 ,不随毛发周期的不同阶段发生周期性变化。透射电镜研究发现在人头发毛囊的玻璃膜位置存在半桥粒结构。结论 :　BPAG2的持续表达说明它对于毛囊的作用主要是参与半桥粒的组成 ,维持结构稳定 。Objective: To investigate the expression of bullous pemphigoid antigen 2 (BPAG2) in different growth stages of hair follicles, and to determine the effects of BPAG2 on hair growth and hair cycles. Methods: Immunofluorescence, immunochemistry, electron microscopy and in situ hybridization were used. Results: Like other components in basal membrane zone (BMZ), such as laminin 5, BPAG2 was persistently present during all stages of hair growth cycles, and it did not change in quantity with the cycles. Electron microscopic examination of human hair follicles demonstrated that hemidesmosomes were located around the dermal-epidermal junctions. Conclusion : It seems that BPAG2 unlikely plays direct role in hair growth and differentiation. This protein may be an important factor in composing hemidesmosome and maintaining the structural integrity of hair follicles.

关 键 词：大疱性类天疱疮抗原2 毛发周期 毛发生长 脱发 毛囊 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]