5-卤代-1H-1,2,4-三氮唑-3-羧酸乙酯及其衍生物的合成  

Synthesis of 5-Halogenated-1H-1,2,4-triazole-3-carboxylic Acid Ethyl Ester and Their Derivatives

作　　者：李德江[1] 孙碧海[2] 李斌[2] 

机构地区：[1]郧阳师范专科学校化学系,湖北丹江口442700 [2]武汉化工学院制药工程系,湖北武汉430073

出　　处：《合成化学》2004年第2期191-193,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以 5 氨基 1H 1 ,2 ,4 三氮唑 3 羧酸乙酯为原料 ,经Sandmeyer反应合成了 5 X 1H 1 ,2 ,4 三氮唑 3 羧酸乙酯 (X =Cl,Br,I) ( 1a～ 1c) ,1a～ 1c再分别与α 2′,4′ 二氟苯乙酮反应合成了 3个 5 卤代 1H 1 ,2 ,4 三氮唑 3 羧酸乙酯衍生物 ( 2a～ 2c) ,其结构通过元素分析 ,IR ,UV和1HNMR进行了表征。5-Halogenated-1H-1,2,4-triazole-3-carboxylic acid ethyl ester(1a～1c) were synthesized from 5-amino-1H-1,2,4-triazole-3-carboxylic acid ethyl ester by Sandmeyer reaction, and their derivatives were prepared by the reaction of 1a～1c with 2′,4′-difluoroacetophenone in the presence of CH 2Cl 2, K 2CO 3 and TEBA. Their structures were confirmed by elemental analysis, IR, UV and 1H NMR.

关 键 词：5-卤代-1H-1 2 4-三氮唑-3-羧酸乙酯 衍生物 合成 表征 

分 类 号：O626.26[理学—有机化学]