2-羟丙基-β-环糊精对桂利嗪的增溶作用  

The solubilization effect of 2-hydroxypropyl-β-cyclodextrin (HPCD) on cinnarizine

作　　者：施洁明[1] 何仲贵[1] 刘晓红[1] 孙英华[1] 李鸿滨[2] 施其海 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]沈阳药科大学集琦药业有限公司,沈阳110016 [3]汇达丰药业有限公司,安庆246000

出　　处：《中国新药杂志》2004年第3期233-235,共3页Chinese Journal of New Drugs

基　　金：国家九五重点科技攻关项目(96-902-02-09)

摘　　要：目的:考察不同pH条件下2-羟丙基-β环糊精对桂利嗪的增溶作用。方法:在37℃运用相溶解度法进行增溶实验,采用紫外分光光度法测定桂利嗪的浓度。结果:随着2-羟丙基β-环糊精浓度增加和pH的减小,桂利嗪的溶解度显著提高。计算了不同pH下包合物的表观稳定常数。结论:对于难溶性药物桂利嗪,2-羟丙基β-环糊精是较理想的增溶剂。Objective: To study the solubilization effect of 2-hydroxypropyl-β-cyclodextrin on cinnarizine at various pH value. Methods: Phase-solubility method was adopted to study the solubilization effect at 37℃ and UV spectrohotometer was used to determine cinnarizine. Results: The apparent solubility of cinnarizine was significantly enhanced by increased HPCD concentration and decreased pH value and the apparent solubility constant was calculated. Conclusion: HPCD is an ideal solubilizer for cinnarizine.

关 键 词：2-羟丙基-Β-环糊精 桂利嗪 溶解度 

分 类 号：R944.9[医药卫生—药剂学] R972.4[医药卫生—药学]