青蒿琥酯钠对约氏疟原虫作用的流式细胞分析  

EFFECT OF SODIUM ARTESUNATE ON PLASMODIUM YOELII ANALYSED BY FLOW CYTOMETRY

作　　者：韩文素[1] 周文琴[1] 王伯霞[1] 李泽民[1] 左连富[2] 郭建文[2] 

机构地区：[1]河北医学院寄生虫学教研室,石家庄市050017 [2]河北省肿瘤研究所,石家庄市050011

出　　处：《中国寄生虫学与寄生虫病杂志》1992年第3期204-207,共4页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：用流式细胞术检测分析了青蒿琥酯钠对鼠约氏疟原虫的作用。结果表明实验组鼠的疟原虫DNA含量随着给药后时间的推移而逐渐减少,24h后,约氏疟原虫DNA的荧光分布几乎消失,提示青蒿琥酯钠能够抑制约氏疟原虫DNA的合成。The effect of sodium artesunate on Plasmodium yoelii-infected mouse erythrocytes was analysed by flow cytometry.The results showed that malarial DNA content in experimental group was obviously decreased 2-5 hours after the drug was administered,fluorescence distribution of malarial DNA almost disappeared within 24 hours after the administration.Thus we deem that sodium artesunate can inhibit the DNA synthessis in P.yoelii.

关 键 词：流式细胞术 青蒿琥酯钠 疟原虫 

分 类 号：R382.31[医药卫生—医学寄生虫学]