抗疟药伯喹的肝微粒体体外代谢的研究  

IN VITRO LIVER MICROSOMAL METABOLISM OF ANTIMALARIAL PRIMAQUINE

作　　者：倪奕昌[1] 王鸣杰[1] 徐月琴[1] 胡铃[1] 

机构地区：[1]中国预防医学科学院寄生虫病研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1992年第4期275-278,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金资助项目;联合国开发计划署/世界银行/世界卫生组织热带病研究培训特别规划资助课题 900391~~

摘　　要：以硅胶薄层层析和高效液相色谱分析法研究了伯喹的肝微粒体体外代谢的主要代谢产物谱。结果表明肝微粒体代谢可同时产生伯喹的喹啉环氧化代谢产物——5-羟基伯喹(5-OH PQ)与侧链氧化脱氨基代谢产物——羧酸伯喹(CPQ);定量比较研究表明在微粒体代谢中前者的生成量远大于后者。The profile of the major metabolites of primaquine produced by in vitro liver microso-mal metabolism was investigated with silica gel thin-layer and high performance liquid chro-matography (HPLC) analysis.The results indicated that the liver microsomal metabolism could simultaneously produce both 5-OH PQ (quinoline ring oxidation product) and CPQ (side-chain oxidative deamination product).However,the quantitative comparative study of microsomal metabolism showed that the production of 5-OH PQ was far much higher than that of CPQ.

关 键 词：肝微粒体 代谢 HPLC 抗疟药 

分 类 号：R978.61[医药卫生—药品]