建立疟疾近期复发动物模型的研究 Ⅱ.食蟹猴疟原虫特殊的环状体原虫血症的持续现象  

STUDIES ON THE ESTABLISHMENT OF MALARIAL ANIMALMODEL OF SHORT-TERM RELAPSE II. THE PHENOMENONOF SUSTAINED SPECIAL RING FORM PARASITEMIAIN PLASMODIUM CYNOMOLGI INFECTION

作　　者：张家埙[1] 林宝英[1] 潘玉蓉[1] 郑浩 方莹[1] 

机构地区：[1]中国预防医学科学院寄生虫病研究所,上海200025

出　　处：《中国寄生虫学与寄生虫病杂志》1992年第4期250-254,共5页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：作者在食蟹猴疟原虫(引自越南)-斯氏按蚊系统的猴疟模型上,利用抗疟药的持效作用,观察到一种特殊的环状体原虫血症,此系红外期裂殖子从肝脏持续释放至血循环中的表现,已获结果显示,环状体原虫血症最长的达53d。经本文研究,此种环状体原虫血症持续现象得到进一步证实。环状体原虫密度随时间的变化,符合Verhulst模型,可用灰色微分方程作数学描述。结果提示,迟缓释放的红外期裂殖子可能为近期复发之源。Our previous report that the EE merozites of Plasmodium cynomolgi from Vietnam continuously released from the liver to the blood circulation was further demonstrated in this report.Monkeys were given pyronaridine 24mg/kg-d×6 after being inoculated intravenously with 32×105 sporzoites of P.cynomolgi.Thick blood film examination was conducted two times daily till the day when trophozoites were detected.Under the residual action of blood schizontocied,a special ring form parasitemia at low patasite-density was detected for more than 30 days.As the ring forms of P.cynomolgi were demonstrated to be susceptible to pyronaridine in our previous experiments,it might be infer red that these ring forms derived from EE merozites released not for once but continuously for 30 days or longer. Furthermore the special ring form parasitemia of infected monkeys after administration with M8132-derivative of dabequiae was also detected.We came to the conclusion just as in the case of pyronaridine.The variation in the ring form parasitemia was coincident with Verhulst model and might be described with the grey differential equation.The authors considered that the short-term relapse might be incuced by the later retease of EE merozoites which multiplied repeatedly in the blood after the drug was excreted and its action disappeared.

关 键 词：疟疾 近期复发 动物模型 疟原虫属 

分 类 号：R531.3[医药卫生—内科学]