孔石莼(Ulva pertusa Kjellm)调血脂作用的初步研究  

STUDY ON THE EFFECT OF THE ACTIVITIES OF ULVA PERTUSA ON RAT'S HYPERLIPAEMIA

作　　者：吴志军[1] 徐祖洪[1] 李智恩[1] 牛锡珍[1] 张红[1] 吴志军 徐祖洪[1] 李智恩[1] 牛锡珍[1] 张红[1] 

机构地区：[1]中国科学院海洋研究所，青岛266071

出　　处：《海洋与湖沼》2004年第2期138-140,共3页Oceanologia Et Limnologia Sinica

基　　金：中国科学院方向性创新资助项目;KZCX3 SW 2 15号

摘　　要：观察孔石莼热水提取多糖和孔石莼乙醇提取物中的有效部位对小鼠实验性高脂血症水平的影响 ,发现孔石莼多糖 2 5 0、5 0 0和 10 0 0mg/ (kg·d)三个剂量组均具有降低小鼠血清总胆固醇 (TC)、甘油三酯 (TG)和低密度脂蛋白胆固醇 (LDL C)的作用 ,而高剂量组具有一定升高高密度脂蛋白胆固醇 (HDL C)的作用 ,其增加HDL C/TC比值显著 (P <0 0 5 )。孔石莼乙醇提取物中的有效部位也具有降低血清TC、TG和LDL C的作用 ,其降TC的作用稍次于孔石莼多糖 ,但其降低TG、升高HDL C/TC比值的作用优于孔石莼多糖。To investigate the effect of the water-soluble polysaccharide and the effective section of the ethanol extract of Ulva pertusa against rat's hyperlipaemia.The rat's experimental model were made by hypercholesterol diet and were fed with three dose 1000mg/(kg·d),500mg/ ( kg·d ),250mg/(kg·d) of polysaccharide and three dose 1.0g/(kg·d),2.0g/(kg·d),3.0g/(kg·d) of the effective section of the ethanol extract of Ulva pertusa . The Chinese traditional medicine Xuezhikang was used as control group and the rat's serum level of TC,TG,LDL-C,HDL-C were examined in the experiment. Three dose of the water-soluble polysaccharide and three dose of the effective section of the ethanol extract of Ulva pertusa had activities to lower the rat's serum level of TC,TG,LDL-C and the high dose can increase the level of HDL-C/TC. The water-soluble polysaccharide and the effective section of the ethanol extract of Ulva pertusa have effects of cholesterol-lowering.

关 键 词：孔石莼 绿藻 多糖 乙醇提取物 高脂血症 调血脂 

分 类 号：Q949.211[生物学—植物学]