乐胃饮对脾虚实验大鼠胃泌素和胃动素的影响  

Experimental Research on Effect of Leweiyin on Gastrin and Motilin in Rats with Spleen Deficiency

作　　者：徐珊 杨青 成信法 朱君华 许家鸾 

机构地区：[1]浙江中医学院,杭州310053

出　　处：《中国医药学报》2004年第1期20-22,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省教育厅科研基金资助项目 ( 2 0 0 2 0 0 46) ;浙江省中医药管理局科研基金资助项目 ( 2 0 0 3C0 0 2 )

摘　　要：目的 :观察乐胃饮对脾虚大鼠胃泌素和胃动素含量的影响 ,探讨乐胃饮治疗胃肠功能性动力疾病的作用机制。方法 :SD大鼠随机分为 7组 ,每组 1 0只 ,2 0 0 %大黄水煎液造脾虚模型。分别给予高中低剂量乐胃饮、西沙必利、香砂六君丸 ,放免法测定血清胃泌素和血浆胃动素。结果 :脾虚大鼠血清胃泌素水平显著降低 ,血浆胃动素水平显著升高 ,乐胃饮治疗组胃泌素含量升高 ,与香砂六君丸组比较 ,P <0 0 1 ,胃动素含量降低。结论 :乐胃饮能使异常改变的胃泌素和胃动素的含量恢复至正常水平 。Objective: To observe the effect of Leweiyin on the contents of gastrin and motilin in rats with spleen deficiency and to disclose the mechanism of Leweiyin in treating functional kinetic disorders of the stomach and intestines. Methods: SD rats were randomly divided into 7 groups ( n =10), and the spleen deficiency model was established by feeding rats with 200% rhubarb decoction. The groups were dealt with high, medium and low dosages of Leweiyin, with Cisapride and with Xiangshaliujun Pill. The gastrin and motilin were measured by radioimmunoassay. Results: Serum gastrin level significantly decreased and plasma motilin increased obviously in the spleen deficiency rats. In Leweiyin group, the content of gastrin increased, compared with Xiangshaliujun Pill group, P <0.01, and the contents of motilin decreased. Conclusion: Leweiyin can regulate the abnormal change of the content of gastrin and motilin to a normal level. It shows that Leweiyin might treat the kinetic disorders of the stomach and intestines by influencing the gastrointestinal hormone level.

关 键 词：乐胃饮 脾虚实验大鼠 胃泌素 胃动素 中药 

分 类 号：R285.5[医药卫生—中药学]