优立新治疗慢性阻塞性肺病和肺心病呼吸道感染的疗效观察  

THE EFFECTS OF UNASYN IN THE TREAMENT OF RESPIRATORY TRACT INFECTIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASES CHRONIC COR PULMONALE

作　　者：陈文彬[1] 刘守智[1] 程德云[1] 梁宗安[1] 李又环[1] 蔡永宁[1] 

机构地区：[1]华西医科大学附属第一医院内科,成都610041

出　　处：《中国抗生素杂志》1992年第1期63-67,共5页Chinese Journal of Antibiotics

摘　　要：应用优立新(青霉烷砜/氨苄苄霉素)和氨苄青霉素分别治疗30例和24例慢性阻塞性肺病和肺心病呼吸道感染。痰菌分离表明其病原菌以革兰氏阴性杆菌占优势。药敏试验提示对优立新高敏者占60.9％,对氨苄青霉素耐药者达87.0％。治疗结果优立新有效率(90.0％)明显高于氨苄青霉素(62.5％)。治疗过程中未发现副作用。说明优立新为一种有效而安全的抗生素。This paper reported the effects of anti-respiratory tract infections of unasyn(consisting of sulbactam.a β-Iactamase inhibitor,ampicillin)on 30 patients with chronic obstructive pulmonary diseases(COPD) or chronic cor pulmonate, and the other 24 patients with the same diseases were treated by ampicillin alone as a control.Results showed that the effective rate of were unasyn (90.0 %) in patients with COPD or chronic cor pulmonale were obviously higher than ampicillin alone(62.5%) . The pathogenic bacteria isolated from the sputa of this group of patients were most-ly found to be gram negative. The drug sensitivity rates of these relevant bacilli toward unasyh or ampicillin indicated 60.9 and 13.0% respectively, and on the contrary the resistant rates were 39.1% and 87.0% respectively.During the course of treatment in this group of patients, no side effects of unasyn were found.WBC, liver and renal functions, blood electrolytes and ECG did not show any abnormalities. We, therefore, consider that unasyn is one of the effective antibiotics with few side effects in the management of patients with COPD or chronic cor pulmonale with infection.

关 键 词：优立新 慢性阻塞性 肺病 肺心病 

分 类 号：R563.05[医药卫生—呼吸系统]