基于样品及点源光声信号逆卷积的光声成像方法  

PHOTOACOUSTIC IMAGING WITH DECONVOLVING THE DETECTED SIGNALS OF SAMPLE BY THE DETECTED SIGNAL OF A POINT SOURCE

作　　者：王毅[1] 邢达[1] 曾亚光[1] 

机构地区：[1]华南师范大学激光生命科学研究所,广州510631

出　　处：《生物物理学报》2004年第2期114-118,共5页Acta Biophysica Sinica

基　　金：国家重大基础研究前期专项(2002CCC00400);国家自然科学基金面上项目(60378043);广东省自然科学基金团队项目(015012)

摘　　要：光声成像是一种新的生物组织成像方法,在目前的光声成像中,都是通过样品光声信号和超声探测器的脉冲响应来计算样品光吸收的投影,但是由于无法获得超声探测器较准确的脉冲响应,影响重建图像质量。提出一种新的计算样品光吸收投影的方法,从理论上给出了样品光吸收投影和样品及点源光声信号的关系,由样品及点源光声信号的逆卷积可直接计算样品光吸收的投影,点源光声信号通过聚焦入射激光直接测得。试验结果显示,重建图像和样品的相对位置、形状及尺寸完全吻合,成像系统空间分辨率达到0.3 mm,证明这是一种有效的光声成像方法。Photoacoustic imaging is a potential novel medical imaging technique to image structures in biological tissue. In the current photoacoustic imaging, the photoacoustic signals detected by a wide-band ultrasonic transducer are deconvolved by the impulse response of the transducer to compute the projection of the optical absorption of the sample, and then reconstruct the optical absorption distribution. But it's difficult to get the exact impulse response of the transducer. A relationship between the projections, detected photoacoustic signals of sample and point source are presented, and the projection can be computed with deconvolving the detected signals of the sample by the detected signal of a point source directly, which can be measured by focusing the incident laser. Experiments demonstrate that the reconstructed images agree well with the original sample. The spatial resolution of the system reaches 0.3 mm.

关 键 词：光声成像 生物组织 样品光声信号 超声探测器 

分 类 号：Q6[生物学—生物物理学] R312[医药卫生—基础医学]