儿茶素和漆黄素对铁超载模型大鼠血脂的影响  

The Effects of Catechin and Fisetin on Blood Lipids of Iron-loaded Mice Model

作　　者：冯星[1] 许东晖[1] 梅雪婷[1] 朱良[1] 陈丽琼[1] 许实波[1] 

机构地区：[1]中山大学药学院,广东广州510275

出　　处：《中山大学学报（自然科学版）》2004年第2期88-90,94,共4页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：2001国家自然科学基金资助项目(30170105);广东省科技计划资助项目(C30402)

摘　　要：分别从中药苞蔷薇根、叶醇提物中分离得到(+)-儿茶素((+)-catechin,CAT)、漆黄素(fisetin,FIS),通过铁超载模型来观察CAT和FIS对铁中毒大鼠血脂的影响。定期饲养大鼠含羰基铁的饲料造成大鼠体内铁超载,给药组在造模的同时给予CAT、FIS或去铁胺(DFO)。给药3个月后,检测血清中的低密度脂蛋白胆固醇(LDL＿CHO)、高密度脂蛋白胆固醇(HDL＿CHO)、总胆固醇(T＿CHO)、甘油三脂的含量(TG)以及血清铁水平。实验结果证明CAT、FIS能非常显著地抑制铁超载大鼠的体重下降,降低血清中铁的含量,抑制血脂中LDL、T＿CHO水平的升高,CAT还可以抑制TG水平的升高。To investigate the effects of catechin(CAT) and fisetin(FIS), which is extracted from Rosa bracteata Wendl, on the of iron_loaded mice.Carbonyl iron was added in the food of mice to make them iron_overloaded model. CAT(3.5,10.5,31.5 mg·kg^(-1),po) and FIS (3.5,10.5,31.5 mg·kg^(-1),po)were treated for 3 months. The level of HDL_Cho, LDL_Cho,T_Cho, TG, Fe^(3+) in serum were tested after 3 months. CAT and FIS could restrain the weight fall of the iron_loaded mice and reduce Fe^(3+) level and LDL level of serum. CAT could also restrain the TG level. CAT has the protective effects on the abnormalities of the iron_overloaded mice.

关 键 词：硕苞蔷薇 (+)-儿茶素 漆黄素 铁超载 血脂 

分 类 号：R559[医药卫生—血液循环系统疾病] R595.2[医药卫生—内科学]