雄兔背部皮下埋植慢释放雄激素药物的实验  

Experimental Study of Transplanted Region of Testicular Prosthesis in vivo

作　　者：刘瑞芝[1] 李希明[2] 雷少琼[1] 陈文明[2] 单春华[1] 董勇治 韩萍[2] 赵钢[1] 郑力[1] 

机构地区：[1]中国科学技术大学生物系 [2]中国科学技术大学应用化学系

出　　处：《中国科学技术大学学报》1992年第4期475-479,共5页JUSTC

摘　　要：将具有慢释放丙酸睾丸甾酮(testosterone propinete(TSP))的聚合物,即雄激素药物,植入摘除了双侧辜丸的雄兔背部皮下定期取血,测定其在体内外的释放水平。利用血球计数和组织切片等方法观测植入雄激素药物后兔子的健康状况。结果表明:雄激素药物在动物体内能长期、稳定地释放丙酸睾丸酮。实验结果与雄激素药物埋植于雄兔阴囊部位的实验结果作了对照分析。这一工作为雄激素药物多种形式的临床应用提供了依据。The testicular prosthesis with slowly released testosterone propionte is implanted subcutaneously in the back of male rabbits whose testes are excised. Then ,at regular intervals, blood is taken and the level of male sex hormone is measured by radioimmunoassery. The measurement results show that the testicular prosthesis has a stable release of male sex hormone in a long period in vivo. In addition, these results are compared with those obtained by transplanting testieular prosthesis into the scrotum of castrated rabbits. This will provide the scientific basis for clinical application of testicular prosthesis on various occasions.

关 键 词：雄激素 丙酸睾丸酮 动物实验 

分 类 号：Q579.11[生物学—生物化学]