羰基锝-EC的制备及其生物分布研究  

Synthesis and biodistribution studies of [^(99)Tc^m(CO)_3-EC] complexes

作　　者：张华北[1] 李波[1] 戴梅[1] 叶海鸿[1] 刘春萍[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《核技术》2004年第4期310-312,共3页Nuclear Techniques

基　　金：国家自然科学青年基金(29801002) 资助

摘　　要：制备了羰基锝-EC并研究了其在小鼠体内的生物分布特征。小鼠体内的活性实验结果表明,羰基锝EC具有高的肾初始摄取和较快的血清除速度,并且有很高的肾清除率(半清除时间小于5min),为羰基锝核在肾功能显像剂方面的应用提供了借鉴。mTc (CO)3-EC] was prepared and its biodistribution in mice was studied. Biodistribution study revealed that it had pretty high initial kidney uptake and fast renal clearance. It would be helpful for further study of carbonyl technetium core used in the field of kidney imaging agents.

关 键 词：肾功能显像剂 羰基锝 生物分布 肾小管分泌 

分 类 号：R916.1[医药卫生—药学] R981.9