A New Cytotoxic Sterol Produced by an Endophytic Fungus from Castaniopsis fissa at the South China Sea Coast  

作　　者：HouJinLI YongChengLIN L.L.P.VRIJMOED E.B.G.JONES 

机构地区：[1]DepartmentofAppliedChemistry,ZhongshanUniversity,Guangzhou510275 [2]DepartmentofBiologyandChemistry,CityUniversityofHongKong,HongKong

出　　处：《Chinese Chemical Letters》2004年第4期419-422,共4页中国化学快报（英文版）

摘　　要：A new sterol, ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A) together with three known sterols: 3β, 5α,6β-trihydroxyergosta-7,22-diene (B), 3β-hydroxy-5α,8α- epidioxyer-gosta-6,22-diene (C) and ergosterol (D) were isolated from the mycelia of an unidentified endophytic fungus separated from Castaniopsis fissa (chestnut tree). Compound A exhibited potent selective cytotoxicity against Bel-7402, NCI4460 and L-02 cell lines with IC50 values 8.445, 5.03, 13.621 μg/mL, respectively.A new sterol, ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A) together with three known sterols: 3β, 5α,6β-trihydroxyergosta-7,22-diene (B), 3β-hydroxy-5α,8α- epidioxyer-gosta-6,22-diene (C) and ergosterol (D) were isolated from the mycelia of an unidentified endophytic fungus separated from Castaniopsis fissa (chestnut tree). Compound A exhibited potent selective cytotoxicity against Bel-7402, NCI4460 and L-02 cell lines with IC50 values 8.445, 5.03, 13.621 μg/mL, respectively.

关 键 词：Endophytic fungus STEROLS ergosta-8(9) 22-diene-3 5 6 7-tetraol (3β 5α 6β 7α 22E) cytotoxicity. 

分 类 号：Q946.48[生物学—植物学]