Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile  

作　　者：XiangGuoSHI DaFangZHONG YuMingSUN YuFengZHANG 

机构地区：[1]LaboratoryofDrugMetabolismandPharmacokinetics,ShenyangPharmaceuticalUniversity,Shenyang110016

出　　处：《Chinese Chemical Letters》2004年第4期431-434,共4页中国化学快报（英文版）

摘　　要：A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI-MSn). Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as Ml serial (spiramycin Ⅰ, Ⅱ, Ⅲ), M2 serial (platenomycin Al, josamycin and leucomycin Al) and M3 serial (deisovalerylplatenomycin Al, deisovaleryl-josamycin, deisovalerylleucomycin Al).A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI-MSn). Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as Ml serial (spiramycin Ⅰ, Ⅱ, Ⅲ), M2 serial (platenomycin Al, josamycin and leucomycin Al) and M3 serial (deisovalerylplatenomycin Al, deisovaleryl-josamycin, deisovalerylleucomycin Al).

关 键 词：SPIRAMYCIN BITESPIRAMYCIN metabolites. 

分 类 号：TQ465[化学工程—制药化工]