肺炎支原体感染患儿外周血单个核细胞CD40L的表达及其临床意义  

Clinical significance of CD40L expression on the peripheral blood mononuclear cells in children with mycoplasma pneumoniae

作　　者：马敏[1] 曹兰芳[1] 陆伟蓉[1] 夏敏[1] 徐凌云[1] 王瑾[1] 卢燕鸣[1] 

机构地区：[1]上海市第二医科大学附属仁济医院儿科,上海200001

出　　处：《临床儿科杂志》2004年第2期91-93,共3页Journal of Clinical Pediatrics

基　　金：上海市科委基金项目 (编号 :004119050)

摘　　要：目的了解CD40L在肺炎支原体 (MP)肺炎及支气管哮喘患儿致病中的作用。方法采用流式细胞仪对26例MP肺炎患儿、24例支气管哮喘合并MP感染患儿、23例支气管哮喘非MP感染患儿和25例正常对照组儿童外周血单个核细胞CD40L的表达进行了研究。结果所有MP肺炎组和支气管哮喘组患儿CD40L表达在PMA和离子霉素 (ionomycin)刺激前后均显著高于正常对照组。结论外周血单个核细胞表面CD40L的表达与支气管哮喘的发病有重要关系 ,MP感染后外周血单个核细胞高表达CD40L可能促进支气管哮喘的发病。Objective To study the pathogenic role of CD40L in patients with mycoplasma pneumoniae(MP) or bronchial asthma.Methods With twenty_six cases with MP pneumoniae,24 cases of bronchial asthma complicated MP,23 bronchial asthma cases without MP and 25 cases as normal control were included in this study.CD40L expression on the peripheral blood mononuclear cells (PBMC) was determined with flow cytometry.Results CD40L expression in children with MP pneumoniae and bronchial asthma was significantly higher than that in normal control before and after being stimulated with PMA and ionomycin.Conclu_ sions There might be an important relationship between higher expression of CD40L and attack of bronchial asthma.CD40L expression on PBMC may play an important role in the pathogenesis of asthma in children with MP pneumoniac.

关 键 词：肺炎支原体 支原体感染 外周血 单个核细胞 CD40L表达 MP 哮喘 肺炎 体液免疫 细胞免疫 

分 类 号：R725.6[医药卫生—儿科]