杨树皮不饱和脂肪酸乙酯化学组成及其药效  

CHEMICAL CONSTITUENTS OF UNSATURATED FATTY ACID ETHYL ESTER FROM POPLAR BARK AND ITS MEDICINE EFFECTIVENESS

作　　者：周维纯[1] 姜紫荣[1] 王金秋[1] 宋强[1] 宋金表[1] 

机构地区：[1]中国林业科学研究院林产化学工业研究所,江苏南京210042

出　　处：《林产化学与工业》2004年第1期73-76,共4页Chemistry and Industry of Forest Products

基　　金：江苏省应用基础研究资助项目(BJ95137)

摘　　要：　杨树(PopulussimoniiCarr.)皮提取物经皂化、萃取、分离和精制,能够得到30%～36%的不饱和脂肪酸乙酯产品。该产品经气相色谱分析,共分离出22个色谱峰,鉴定出21个化合物,其中主要的不饱和脂肪酸乙酯成分为亚油酸乙酯,含量高达94.04%。已鉴定的组分占产品总量的99.19%,其中不饱和脂肪酸酯占95.94%,饱和脂肪酸酯占3.14%。药效试验证明,杨树皮不饱和脂肪酸乙酯产品能显著降低试验性高脂血症大鼠的血清总胆固醇(TC)、甘油三脂(TG)和低密度脂蛋白的胆固醇(LDL-C)水平(P<0.001),而对血清中高密度脂蛋白的胆固醇(HDL-C)含量有升高作用。Unsaturated fatty acid ethyl ester product was obtained from poplar bark extract through saponification,(extraction),separation and purification,at yield 30%-36% of the extract.It consists of 95.94% esters of unsaturated fatty acid and 3.14% esters of saturated fatty acid.This product is analysed by GC.Of the 22 peaks,21 components which make up (99.19%) of the total weight were identified.The major component is linoleic acid whose content reached 94.04%.Medicine effectiveness test of the product showed that TC,TG and LDL-C in serum of high blood-(lipoid) rats(P<0.001) can be reduced obviously and content of HDL-C in serum is increased.

关 键 词：杨树皮 不饱和脂肪酸乙酯 化学组成 药效 心血管系统药物 

分 类 号：R284.1[医药卫生—中药学] Q949.733[医药卫生—中医学]