点—免疫结合法检测抗SSA抗体的临床研究  

Clinical study on anti—SSA antibody by using dot immunobinding assay

作　　者：蒋明[1] 周淑洁[1] 寇中琛 阎春丽 王春豹 史艳萍[1] 曾小峰[1] 

机构地区：[1]北京协和医院内科免疫组,北京100005

出　　处：《中国免疫学杂志》1992年第5期311-313,共3页Chinese Journal of Immunology

摘　　要：自人脾提取和纯化 SSA 抗原,建立了点-免疫结合测定抗 SSA 抗体的方法,经与免疫双扩散法比较,具有特异性较高的特点.抗 SSA 抗体在干燥综合征患者血清中的阳性率为76.9%,而在系统性红斑狼疮患者血清中的阳性率为33.3%,抗 SSA 抗体常与类风湿因子同时存在.Using human spleen purified SSA antigen,we set up a new technique of dot immunobinding assay(DIBA) for detection of anti—SSA antibody.The specificity of DIBA is better than that of double immunodiffusion method.The positive rate of anti—SSA antibody in Sjogren syndrome is 76.9%,while that in systemic lupus erythematosus is 33.3%.We found that anti—SSA antibody and RF usually appeared in same patient with Sjo-gren syndrome or rheumatoid arthritis.

关 键 词：抗SSA抗体 干燥综合征 

分 类 号：R442.8[医药卫生—诊断学]