盐酸胺碘酮的线性扫描极谱法测定及电化学行为研究  

Study on Linear Sweep Polarography of Amiodarone Hydrochloride

作　　者：谭学才[1] 翟海云[1] 李荫[1] 蔡沛祥[1] 

机构地区：[1]中山大学化学与化学工程学院

出　　处：《分析测试学报》2004年第2期52-55,共4页Journal of Instrumental Analysis

基　　金：广西壮族自治区自然科学基金资助项目 (0141037;0342018) ;广西民族学院重点资助项目 (OHHX00002)

摘　　要：在0.2mol/LNa2HPO4-KH2PO4(pH=6.82)支持电解质中 ,盐酸胺碘酮有一灵敏的极谱还原波 ,其峰电位VP= -1.30V(vsSCE) ,一阶导数峰电流IP 与盐酸胺碘酮的浓度在1.0×10 -7～2.0×10 -6mol/L呈良好的线性关系 (r=0.9975 ,n=11) ,检出限为5.0×10-8 mol/L ;采用标准加入法测定了片剂中盐酸胺碘酮的含量 ,其回收率在95.0 %～99.5 %之间 ;用多种电化学方法研究了盐酸胺碘酮的电化学行为 ,结果表明其电极过程为一具有吸附性和动力性的不可逆极谱波。实验测得电极反应的电子转移数、转移系数和参与电极反应的H +数分别为2、0.62和2。A sensitive derivative reduction peak of amiodarone hydrochloride(ADHC) in 0.2 mol/L Na2HPO4-KH2PO4(pH=6.82) supporting electrolyte was obtained by linear-sweep polarography. The linear range of the calibration curve was 1.0×10-7～2.0×10-6 mol/L(r=0.997 5) with a detection limit of 5.0×10-8 mol/L. The method has been successfully used for the determination of ADHC concentration in medical tablets. The standard addition recovery was 95.0%～99.5%. The electrochemical behavior of the system was studied by means of linear-sweep polarography and cyclic voltammetry. The results showed that the electrode process was an irreversible one with typical adsorptive and kinetic characteristics. The electron transfer numbers and the transfer coefficient of the electrode reaction as well as the proton numbers participating in it were found to be 2, 0.62 and 2, respectively.

关 键 词：盐酸胺碘酮 线性扫描极谱法 电化学行为 抗心律失常药 片剂 含量测定 

分 类 号：R972.2[医药卫生—药品] R927.2[医药卫生—药学]