阻塞性睡眠呼吸暂停低通气综合征模型鼠软腭的力学重建  

Mechanical Remodeling in the Soft Palate of a Rat OSAHS Model

作　　者：刘永义[1] 包亚军[1] 刘文华[1] 姚大康[2] 覃开蓉[3] 

机构地区：[1]中国人民解放军第359医院耳鼻喉科,江苏镇江212001 [2]江苏理工大学生物医学工程研究所,江苏镇江212013 [3]复旦大学生物力学实验室,上海200433

出　　处：《医用生物力学》2004年第1期27-30,共4页Journal of Medical Biomechanics

基　　金：国家自然科学基金资助项目 (No :10 2 72 112 )

摘　　要：目的　研究阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)咽腔呼吸压力对软腭力学特性的影响。方法　用SD鼠建立OSAHS动物模型 ,对动物模型的软腭进行单轴拉伸实验 ,离体检测软腭的弹性。结果　通过对照正常生理状态下SD鼠的实验结果 ,比较研究与OSAHS有关的软腭力学特性的变化规律和软腭重建现象。结论　实验研究表明 。Objective To investigate the effects of pharyngeal respiratory pressure on the mechanical properties of soft palate in obstructive sleep apnea hypornea syndrome (OSAHS). Methods An animal model of OSAHS was developed from SD rats, and the elastic properties of the soft palate of the rat model were measured in vitro through uniaxial tensile experiments. Results To compare with the control one, the mechanical properties of the soft palate and the phenomenon of its remodeling related to OSAHS were discussed. Conclusion It was shown that pharyngeal respiratory pressure analogous to that of OSAHS episodes can cause the soft palate remodeling prone to OSAHS's formation and development.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 咽腔呼吸压力 软腭重建 

分 类 号：R318.01[医药卫生—生物医学工程]