联用东莨菪碱治疗急性有机磷中毒临床观察  

The Clinical Obaervation in Combine Treatment with Atropine and Scopoiamine for Acute Orgnaic Phosphoras Poinoaing(AOPP)

作　　者：付守芝[1] 李孝全[1] 刘克英[1] 

机构地区：[1]湖北省十堰市人民医院急诊科,十堰442000

出　　处：《临床急诊杂志》2004年第2期14-15,共2页Journal of Clinical Emergency

摘　　要：目的:探讨急性有机磷中毒(AOPP)患者用阿托品和阿托品加东莨菪碱治疗对血胆碱脂酶(ChE)的影响和临床疗效。方法:100例患者入院后采用单盲法分组,用阿托品加其它综合治疗作为对照组,阿托品加东莨菪碱加其它综合治疗作为治疗组,按标准分为轻、中、重三度,分别于治疗前,治疗后12、24、48、72 h抽血测定ChE活性值,记录达到阿托品化时间。结果:ChE在中毒患者治疗前无差异,治疗后12 h有差异,24、48及72 h治疗组明显高于对照组(P<0.01)。结论:AOPP治疗中通过ChE变化观察,阿托品加东莨菪碱较单纯使用阿托品效果更好,能减少阿托品用量,缩短阿托品化时间,减轻阿托品的毒副作用,亦可减少中间综合征的发生。Objective:To study treatment of AOPP patients with atropine and atropine plus scopolamine respectively and to observe the change of the blood chilne esterase and clinical effect of its treatment Methods: 100 patients were randomly divided into two groups after ad-minsson to hospital with a single - blind way. The tint group was treated with atropine and other comprehensive treatment The other group was treated with atropine and scopolamine plus other comprehensive treatment before and after treatment within 12 hours,24 hours,48 hours and 72 hours choline esterase were measure the respectively. Results: Before the treatment, the ChE of the patients had little change, 12 hours after the treatment,the blood ChE of the first group was hinger than that of the second group ( P <0. 05) ,48 houn and 72 hours after the treatment, the blood ChE was obviously higher than that of the second group( P <0. 01). Conclusion:Treatment with scopolamine plus atropine is better than treatment only with atropine and would reduce the side effect of the poisoning of atropine as well as other attached diseaaes.

关 键 词：东莨菪碱 急性有机磷中毒 临床观察 阿托品 血胆碱脂酶 中间综合征 

分 类 号：R971.92[医药卫生—药品] R595.4[医药卫生—药学]