在Phen-Cu-Vc系统中肌肽对DNA损伤的作用  

Functions of Carnosion on DNA Damage induced by Phen-Cu-Vitc System

作　　者：黄进[1] 杨国宇[1] 李宏基[1] 熊程辉[1] 李留安[1] 王政[1] 

机构地区：[1]河南农业大学,河南郑州450002

出　　处：《微量元素与健康研究》2004年第2期1-3,共3页Studies of Trace Elements and Health

基　　金：河南省杰出青年科学基金 ( 0 3 1 2 0 0 1 5 0 0 )

摘　　要：采用TBA法在脱氧核糖水平上研究了肌肽对Phen -CuSO4-Vc系统引起的DNA损伤的作用 ,并对其作用机理作了初步探讨。同时设甘露醇、苯甲酸钠、二甲基亚砜作对照 ,发现肌肽对DNA损伤的保护作用明显优于甘露醇、苯甲酸钠。The effects of carnosine on DNA damage induced by ascorbate Cu-phenanthroline system was studied on deoxyribose level, using TBA reaction, and made some analysis on the mechanism carnosine protect DNA. The protect effects of Mannitol?Benzoate and Dimethylsulfoxide also been studied. It was suggested that carnosine has a higher protect effect that Mannitol?Benzoate and Dimethylsulfoxide in the right systerm.

关 键 词：肌肽 羟基 DNA损伤 TBA反应 

分 类 号：O623[理学—有机化学]