分子印迹聚合物拆分消旋体酮洛芬  

Separation of racemic ketoprofen by molecularly imprinted polymer

作　　者：姜吉刚[1] 任建成[1] 许丽晓[1] 王怀友[1] 

机构地区：[1]山东师范大学化学系,济南250014

出　　处：《分析试验室》2004年第3期56-58,共3页Chinese Journal of Analysis Laboratory

摘　　要：以(S) 酮洛芬为印迹分子利用分子印迹技术合成能识别(S) 酮洛芬的聚合物。聚合物作为高效液相色谱的固定相,消旋体酮洛芬在固定相能分开,同时聚合物还能将酮洛芬和布洛芬的混合物分开。By using (S)-ketoprofen as a template, a kind of polymer which can recognze (S)-ketoprofen was prepared by molecular imprinting technique. Racemic ketoprofen was separated when the polymer was used as a stationary phase of high performance liquid chromatography. The mixture of ketoprofen and ibuprofen were also separated by this polymer.

关 键 词：药物 酮洛芬 手性拆分 分子印迹聚合物 高效液相色谱 

分 类 号：R917[医药卫生—药物分析学]