常通口服液对大鼠实验性肠粘连的实验研究  

Experimental Research on the Effects of "Chang Tong Oral Liquid" on Experimental Intestinal Adhesion in Rats

作　　者：王春霞[1] 侯连兵[1] 

机构地区：[1]第一军医大学南方医院,广州510515

出　　处：《中药材》2004年第4期272-274,共3页Journal of Chinese Medicinal Materials

基　　金：国家新药研究基金(编号 :96 90 1 0 5 2 45 )

摘　　要：目的 :研究常通口服液对实验性肠粘连大鼠的防治效果。方法 :选用SD雄性大鼠 ,手术造成肠粘连模型。各组治疗 7天后取血 ,测定TNF α含量 ,并记录大鼠肠粘连级别。结果 :模型组的TNF α含量与正常组比较有显著性差异 (P <0 0 0 1) ,常通口服液低、中、高剂量组与模型组比较均能显著降低TNF α含量 (P <0 0 0 1)。结论 :常通口服液能降低术后肠粘连级别和血清中TNF α含量。Objective: To study the efficacy of 'Chang Tong Oral Liquid'(CTOL) on the degree of intestinal adhesion in rats after surgery Methods: SD rat model of intestinal adhesion was made by surgery After each group was treated continuously for 7 days, serum TNF α level was determined and the degree of intestinal adhesion was graded Results: There was a significant difference between the level of TNF α in model group and those in normal group(P<0 001). The level of TNF α was remarkably decreased by small, medium and big dose of CTOL, as compared with that of model group(P<0 001) Conclusion: CTOL can significantly decrease the graded scores of intestinal adhesion and serum TNF α level It suggested that CTOL could cure adhesion of intestine in rats

关 键 词：常通口服液 大鼠 实验性肠粘连 实验研究 TNF-Α 

分 类 号：R259.74[医药卫生—中西医结合]