药物体外ADME筛选模型  

In Vitro Models Used to Screen for Human ADME Drug Properties

作　　者：杨建波[1] 姚佳[1] 杨洁[1] 

机构地区：[1]南京大学医药生物技术国家重点实验室,江苏南京210093

出　　处：《药学进展》2004年第4期163-168,共6页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目 (30 1710 94 ;30 2 714 97)

摘　　要：目前已有很多基于细胞水平的体外模型用于研究药物的吸收、分布、代谢、消除和药物毒性 ,以提高药物开发的成功率。如用于肠吸收研究的CaCo 2细胞模型。Drug properties in absorption,distribution,metabolism,excretion and toxicity significantly affect the success of a drug emerging in the market. Many in vitro models at cell level have been designed to investigate these properties. The CaCo 2 cell model used for absorption investigation, the liver cell model used for metabolism or toxicity investigation, and the cell models used to estimate the efficiency of the drug uptake through the blood brain barrier were introduced in this review. [

关 键 词：药物筛选 ADME模型 血脑屏障 药物开发 药物吸收 药物分布 

分 类 号：R965.1[医药卫生—药理学]