由动物实验估算人体内^(13)N-NH-3·H-2O辐射吸收剂量  

Human dosimetry estimation of ^(13)N-NH-3·H-2O based on mice biodistribution data

作　　者：唐刚华[1] 王明芳[1] 唐小兰[2] 吴湖炳[1] 黄祖汉[1] 

机构地区：[1]第一军医大学南方医院南方PET中心,广州510515 [2]华南农业大学理学院,广州510642

出　　处：《辐射研究与辐射工艺学报》2004年第2期97-100,共4页Journal of Radiation Research and Radiation Processing

摘　　要：由小鼠体内分布资料估算N-氨水(13N-NH3?H2O)在人体内辐射吸收剂量,并评价其安全性。由小鼠13尾静脉注射N-NH3?H2O后,在0、0.5、1、2、5、10、20、30min时刻处死动物,测定小鼠体内各脏器放13射性分布,换算至标准人体内分布数据,按MIRD法计算人体内N-NH3?H2O辐射吸收剂量。经估算,人体13肝内照射吸收剂量最高,其值为3.6×10-3mGy/MBq,全身内照射吸收剂量最低,约为1.7×10-3mGy/MBq,其他脏器内照射吸收剂量在(2.4—3.3)×10-3mGy/MBq之间,有效剂量为1.8×10-3mSv/MBq。由小鼠体内分布资料可估算人体内N-NH3?H2O吸收剂量,这些资料为临床安全应用N-NH3?H2O提供了依据。Based on mice biodistribution data, absorbed doses in humans due to intravenous administration of 13N-NH3 ? H2O can be estimated, so as to evaluate the safety of PET diagnosis with 13N-NH3 ?H2O in humans. 13N-NH3 ? H2O was injected into mice through a tail vein. At 0, 0.5, 1, 2, 5, 10, 20 and 30 min after the injection, the mice were killed by cervical fracture and biodistribution in mice was determined. Radiation dosimetry in humans was calculated on the base of organ distribution in mice and the standard MIRD method using radioactivity-time curves for humans. The liver in humans received the highest dose of 3.6×10-3 mGy/MBq. The whole body received the lowest dose of 1.7×10-3 mGy/MBq, and other organs received doses between 2.4 ×10-3 and 3.3 ×10-3 mGy/MBq. The effective dose was estimated to be 1.8×10-3 mSv/MBq. These results were comparable to values of absorbed doses reported by other authors on radiation dosimetry of this radiopharmaceutacal. Human radiation dosimetry can be performed by the mice biodistribution data and important data for clinical safe trial of N-NH3 ? H2O are provided. 13

关 键 词：动物实验 辐射吸收剂量 放射性药物 体内生物分布 正电子发射断层显像 质量控制 放射性摄取率 

分 类 号：R817.4[医药卫生—影像医学与核医学]