3-芳胺甲烯基-6-甲基-6-胡椒基-5,6-二氢-2H-吡喃-2,4二酮的合成及杀菌活性  

Synthesis and Fungicidal Activity of 3-Anilinomethylene-5,6-dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-diones

作　　者：邱克明 王有名[2] 何可[2] 

机构地区：[1]湖南省张家界市环保局,湖南张家界427000 [2]元素有机化学重点实验室南开大学元素有机化学研究所,天津300071

出　　处：《精细化工中间体》2004年第2期11-13,24,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金青年基金资助(20302003)。

摘　　要：采用乙酰乙酸乙酯的双负离子与胡椒基甲基酮反应,合成了5,6 二氢 6 甲基 6 胡椒基 2H 吡喃 2,4 二酮,然后与原甲酸三乙酯、芳胺进行缩合反应,得到了3 芳胺甲烯基 5,6 二氢 6 甲基 6 胡椒基 2H 吡喃 2,4 二酮,其结构经1HNMR和元素分析证实。生物活性初步测定表明,该类化合物具有一定的杀菌活性。5, 6-Dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-dione, which was obtained by reacting dianion of acetoacetate with piperonyl methyl acetone, reacted with substituted anilines in the presence of ethyl orthoformate and 3-anilinomethylene-5, 6-dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-diones (2) were obtained.The Structures of compounds 2 were confirmed by 1~H NMR spectra and elemental analyses. Compound 2 was tested in vitro against many fungi such as P. Zeae, A. Solani, R. Solani, P. Piricola, C. Arachidicala. The bioassay results showed that they have some fungicidal activity.

关 键 词：双负离子 胡椒基甲基酮 杀菌 

分 类 号：TQ455[化学工程—农药化工]