阿斯匹林对全脑缺血大鼠记忆功能的影响  

Effect of aspirin on learning and memory in the cerebral ischemia rats

作　　者：罗伟[1] 壮荣[1] 吴昊[2] 刘利兵[2] 刘芳娥[2] 陈健康[2] 杨芳[2] 

机构地区：[1]解放军第四军医大学学员旅1队,710032 [2]解放军第四军医大学基础部基础医学教学实验中心,710032

出　　处：《中国行为医学科学》2004年第2期142-144,共3页Chinese Journal of Behavioral Medical Science

摘　　要：目的观察阿斯匹林 (aspirin ,As)对短暂性全脑缺血大鼠学习记忆的影响。 方法用反复夹闭双侧颈总动脉结合腹腔注射硝普钠的方法建立短暂性全脑缺血大鼠模型 ;将大鼠分为模型组、假手术组和给药组 ,以Y型迷宫、水迷宫检测大鼠的学习记忆能力 ;光镜检测海马细胞的损伤。结果在Y型迷宫实验中模型组、假手术组、给药组的学习成绩分别为 :18.0 0min、9.0 0min、11.5 7min ,记忆成绩分别为 :11.80次、17.17次、15 .2 9次。水迷宫实验中模型组、假手术组、给药组的学习成绩分别为 :2 19s、87s、15 1s ,记忆成绩分别为 :46s、9s、2 7s。光镜检测也发现阿斯匹林可以显著的减少全脑缺血大鼠的海马CA1区锥体细胞的损伤。结论阿斯匹林对短暂性全脑缺血损伤海马大鼠的学习记忆水平有一定的改善作用。ObjectiveTo observe the effect of aspirin as on a model of cerebral ischemia rats. Methods The cerebral ischemia rat model was established by repeatedly clipping the common carotid artery of the rat in combination with reducing the rat’s blood pressure with an abdominal injection of sodium nitroprusside. The rats were separate into model group, normal group, normal+As group; the learning and memory were observed by Y-maze and water-maze; the death of hippocampal cells were detected by using microscope. ResultsY-maze test effect of learning is that model group rats are succeed at the learning averagely in 18.00min; normal group in 9.00min; normal+As group in 11.57min.Y-maze test effect of memory is that model group rats have 11.80 successful tests in the 20 memory tests averagely; normal group rats have 17.17; normal+As group rats have 15.29. Water-maze test effect of learning is that model group succeed in 219s; normal group in 87s; normal+As group in 151s. Water-maze test effect of memory is that model group succeed in 46s; normal group in 9s; normal+As group in 27s. Aspirin was shown to decrease injury in hippocampal CA1 region cells of the cerebral ischemia rats significantly in microscope. ConclusionAspirin has improve effects on learning and memory in the cerebral ischemia rats.

关 键 词：脑缺血 海马 迟发性神经元坏死 阿斯匹林 

分 类 号：R965[医药卫生—药理学]